【产品介绍】：

产品名称 Narciclasine 英文名称 Narciclasine 规格或纯度 ≥98% 别名 (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one 英文别名 (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one 运输条件 超低温冰袋运输 生化机理 Narciclasine modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization. The cytostatic activity of Narciclasine involves the impairment of actin cytoskeleton organization by targeting GTPases, including RhoA and the elongation factor eEF1A. Thus, Narciclasine is a potentially promising agent for the treatment of primary brain cancers and various brain metastases. Also Narciclasine is an actin stress fiber formation inducer; a plant growth modulator.Plant growth\xa0regulator originally\xa0isolated from Narcissus bulbs. Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC 50 = 47 nM). Activity decreasesCAS编号 29477-83-6 溶解性 DMSO 储存温度 -20°C储存 MDL号 MFCD01729949 分子量 307.26 分子式 C14H13NO7 PubChem CID 72376