【产品介绍】：

(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2 (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2 产品名称 (-)-表没食子儿茶素没食子酸酯 产品名称 (-)-Epigallocatechin gallate 别名 3-没食子酸酯;EGCG 英文别名 (-)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate); Teavigo; CAS编号 989-51-5 分子式 C22H18O11 分子量 458.37 PubChem CID 65064 MDL号 MFCD00075940 Beilstein 17(5)8,506 Reaxys-RN 67944 Merck Index 3526 规格或纯度 分析标准品 应用 An inhibitor of Bcl-2 and NOS2 备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 生化机理 (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, with broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDL) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. After treating with EGCG, the expressions of HES1 and Notch2 was obviously inhibited, this indicated that EGCG inhibited colorectal cancer by inhibiting HES1 and Notch2.Potent antioxidant flavonoid. Displays anticancer, antitumour activity and induces apoptosis. Modulates numerous cell signalling pathways, such as inhibiting NF-κB, MAPK and COX-2 pathways. 熔点 212°C 比旋光度 -175.5 ° (C=1, EtOH) 溶解性 Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol. 储存温度 2-8°C储存 运输条件 冰袋运输 密度 1.9