【产品介绍】：

Name:BAY 1251152
Synonyms:(+)-BAY-1251152
CAS Number:1610358-56-9
Formula:C19H18F2N4O2S
M.w.:404.43
DMSO (mg/mL)Max Solubility:81
DMSO (mM)Max Solubility:200.28
Form:free base
SMILES:COC1=C(C=CC(=C1)F)C2=CC(=NC=C2F)NC3=NC=CC(=C3)C[S](C)(=N)=O
ALogP:4.677
Target:CDK
Pathway:Cell Cycle
Information:BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins.
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