【产品介绍】：

Name:PDGFR inhibitor 1
Synonyms:N/A
CAS Number:1225278-16-9
Formula:C26H21F2N5O3
M.w.:489.47
DMSO (mg/mL)Max Solubility:97
DMSO (mM)Max Solubility:198.17
Form:free base/salt
SMILES:C[N]1C=C(C=N1)C2=NC=CC(=C2)OC3=CC(=C(NC(=O)C4(CC4)C(=O)NC5=CC=CC=C5)C=C3F)F
ALogP:3.841
Target:c-Kit,CSF-1R,PDGFR,VEGFR
Pathway:Protein Tyrosine Kinase
Information:PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of Kit (c-Kit) and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.
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