【产品介绍】：

Name:Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
Synonyms:CA 4DP
CAS Number:168555-66-6
Formula:C18H19O8P.2Na
M.w.:440.29
DMSO (mg/mL)Max Solubility:<1
DMSO (mM)Max Solubility:N/A
Form:Disodium salt
SMILES:[Na+].[Na+].COC1=C(O[P]([O-])([O-])=O)C=C(\C=C/C2=CC(=C(OC)C(=C2)OC)OC)C=C1
ALogP:1.077
Target:Apoptosis related,Microtubule Associated
Pathway:Cytoskeletal Signaling
Information:Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
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