【产品介绍】：

生物活性：MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
IC50 & Target：Auristatin
体外研究(In Vitro)：MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
MMAD-d8 相关抗体:
alpha Tubulin Antibody
LC3A/B Antibody
Beta Tubulin Antibody
beta Tubulin Antibody (YA839)
Doublecortin Antibody
LC3B Antibody (YA308)
Stathmin 1 Antibody (YA049)
Stathmin 1 Antibody (YA050)
alpha Tubulin (acetyl K40) Antibody
beta III Tubulin Antibody
gamma Tubulin Antibody
LC3B Antibody
Beta Tubulin Antibody (HRP) (YA865)
Cytokeratin 5 Antibody
MAP2 Antibody
DM1 Antibody (YA898)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
CK18 Antibody
Cytokeratin 19 Antibody
Cytokeratin 7 Antibody (YA951)
Cytokeratin 15 Antibody (YA1493)
p63 Antibody (YA1531)
Cytokeratin 6 Antibody (YA1701)
Cytokeratin 4 Antibody (YA1762)
Cytokeratin 10 Antibody (YA1857)
Cytokeratin 14 Antibody (YA1876)
Cytokeratin 1 Antibody (YA2665)
Stanniocalcin 1 Antibody (YA2690)
Cytokeratin 13 Antibody (YA2695)
体内研究(In Vivo)
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：779.11
Formula：C41H58D8N6O6S
非标记 CAS：203849-91-6
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。