【产品介绍】：

生物活性：3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
3-O-Methyldopa-d3 hydrate 相关抗体:
IL-1 beta Antibody
EpCAM Antibody (YA772)
IL-1 beta Antibody (YA345)
CD127 Antibody
EpCAM Antibody (YA458)
IL-18 Antibody
IL-4 Antibody (YA343)
IL-6 Antibody
SOCS1 Antibody
IL-8/CXCL8 Antibody
IL-10 Antibody
IL17A Antibody
IL-1 alpha Antibody
IL-6R Antibody
IL-13 Receptor alpha 1 Antibody (YA1624)
FMO3 Antibody (YA1992)
IL-12 beta Antibody (YA2753)
IL-32 Antibody (YA2911)
IL-11 Receptor alpha Antibody (YA3092)
SOCS2 Antibody
CEACAM1 Antibody
CEA Antibody (YA917)
IL-19 Antibody
IL-4I1/LAO Antibody (YA1225)
IL-5 Receptor alpha Antibody (YA1228)
SIRP alpha Antibody (YA1361)
IL-13RA1 Antibody (YA1377)
IL-17RA Antibody (YA1379)
IL-2 Antibody (YA1454)
IL-2RA Antibody (YA1457)
分子量：232.25
Formula：C10H12D3NO5
非标记 CAS：300-48-1
中文名称：3-O-甲基多巴 d3 (水合物)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Masato Asanuma, et al. 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci. 2016 Jul 25;17(1):52.
 [Content Brief]