【产品介绍】：

生物活性：Palbociclib-d4 (hydrochloride) is the deuterium labeled Palbociclib hydrochloride. Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Palbociclib-d4 hydrochloride 相关抗体:
Cyclin E1 Antibody (YA483)
CD133 Antibody
Cdk2 Antibody
Cdk4 Antibody
Cdk5 Antibody
Cdk6 Antibody
Cyclin D3 Antibody
Cdk7 Antibody
CDK16 Antibody
CDK5 Antibody (YA796)
CDK9 Antibody
CDKN2A/p16INK4a Antibody (YA508)
Phospho-CDK1 (Tyr15) Antibody
Phospho-CDK1/2/3 (Thr14) Antibody
Phospho-CDK2 (Tyr15) Antibody
Phospho-Cyclin B1 (Ser126) Antibody
CDKN2A/p16INK4a Antibody
CDKN2C Antibody
Phospho-CDC6 (Ser54) Antibody (YA1017)
Cyclin E2 Antibody (YA2594)
CDC25C Antibody (YA2624)
CDC6 Antibody (YA2626)
CDC40 Antibody (YA3168)
Cyclin A1/A2 Antibody (YA3336)
CRK Antibody (YA790)
Cyclin H Antibody (YA788)
Cyclin H Antibody
Phospho-CDC6 (Ser106) Antibody (YA1016)
CDC7 Antibody (YA1152)
Cyclin D3/CCND3 Antibody (YA1201)
分子量：488.02
Formula：C24H26D4ClN7O2
非标记 CAS：571190-30-2
中文名称：帕布昔利布 d4 (盐酸盐)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
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[3]. Katsumi Y, et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun, 2011, 413(1), 62-68.
 [Content Brief]
[4]. Goel S, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 Aug 24;548(7668):471-475.
 [Content Brief]