【产品介绍】：

生物活性：D8-MMAF hydrochloride is a deuterated form of MMAF hydrochloride. MMAF Hydrochloride, a potent tubulin polymerization inhibitor, is used as a antitumor agent and a cytotoxic component of antibody-drug conjugates (ADCs)[1].
IC50 & Target：Auristatin
体外研究(In Vitro)：MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
MMAF-d8 相关抗体:
alpha Tubulin Antibody
LC3A/B Antibody
Beta Tubulin Antibody
beta Tubulin Antibody (YA839)
Doublecortin Antibody
LC3B Antibody (YA308)
Stathmin 1 Antibody (YA049)
Stathmin 1 Antibody (YA050)
alpha Tubulin (acetyl K40) Antibody
beta III Tubulin Antibody
gamma Tubulin Antibody
LC3B Antibody
Beta Tubulin Antibody (HRP) (YA865)
Cytokeratin 5 Antibody
MAP2 Antibody
DM1 Antibody (YA898)
MMAE Antibody (YA899)
MMAF Antibody (YA900)
CK18 Antibody
Cytokeratin 19 Antibody
Cytokeratin 7 Antibody (YA951)
Cytokeratin 15 Antibody (YA1493)
p63 Antibody (YA1531)
Cytokeratin 6 Antibody (YA1701)
Cytokeratin 4 Antibody (YA1762)
Cytokeratin 10 Antibody (YA1857)
Cytokeratin 14 Antibody (YA1876)
Cytokeratin 1 Antibody (YA2665)
Stanniocalcin 1 Antibody (YA2690)
Cytokeratin 13 Antibody (YA2695)
体内研究(In Vivo)
The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：740.01
Formula：C39H57D8N5O8
非标记 CAS：745017-94-1
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (539 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Lee BI, et al. Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody-Drug Conjugate. Molecules. 2020;25(7):1515. Published 2020 Mar 26.
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