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Forskolin是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，常用来提高cAMP水平。An adenylate cyclase activator and MAP kinase inhibitor 安全信息 RTECS QL6150000 WGK 3 属性 产品名称 佛司可林 产品名称 Forskolin 别名 佛司可林;毛喉素;7β-乙酰氧基-8,13--环氧-1α,6β,9α-三羟基labd-14-烯-11-酮;考福新;洋紫苏醇 英文别名 Coleonol;Colforsin;Boforsin; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one CAS编号 66575-29-9 分子式 C22H34O7 分子量 410.5 PubChem CID 47936 MDL号 MFCD00082317 Beilstein 1692720 Merck Index 2476 规格或纯度 ≥98% 应用 An adenylate cyclase activator and MAP kinase inhibitor 备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 生化机理 Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, platelet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet antiaggregatory and antihypertensive actions in vivo . 熔点 224.0 to 228.0°C 比旋光度 -17° 溶解性 Soluble in DMSO (5 mg/ml), ethanol, methanol, and Chloroform.Insolule in water. 储存温度 -20°C储存 运输条件 超低温冰袋运输 Hu S et al.  et al (2019) Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats. 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