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Lamotrigine是一种新型抗惊厥药剂，作用于人类血小板和大鼠脑突触体，抑制5-羟色胺(5-HT)吸收，IC50分别为240 μM和474 μM。A sodium channel protein inhibitor. 安全信息 标识符号 GHS06 信号词 Danger 危害声明 H301 警示性声明 P301+P310 RTECS XY5850700 WGK 3 属性 产品名称 拉莫三嗪 产品名称 Lamotrigine 别名 拉莫三嗪;LTG 英文别名 GI 267119X;6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; Lamictal; Epilepax; LTG; BW430C CAS编号 84057-84-1 分子式 C9H7Cl2N5 分子量 256.09 PubChem CID 3878 MDL号 MFCD00865333 EC号 281-901-8 Merck Index 5353 规格或纯度 ≥98% 应用 A sodium channel protein inhibitor. 备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 生化机理 Lamotrigine is a phenyltriazine sodium channel protein inhibitor of presynaptic neurons. Studies indicate that Lamotrigine blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine. Futhermore, Lamotrigine displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents. Lamotrigine is an inhibitor of Serotonin.Anticonvulsant. Active in vivo and orally bioavailable. Various pharmacological activities including sodium channel blocking (K i = 9 μM). Selectively inhibits seizure discharges over normal neuronal activity. 熔点 216-218°C 敏感性 对热和空气敏感 溶解性 Soluble in DMSO (12 mg/mL) at 40 °C, ethanol (12 mg/mL) at 40 °C, DMF (25 mg/mL), methanol, and dilute hydrochloric acid (slightly soluble). Insoluble in water. 储存温度 2-8°C储存 运输条件 冰袋运输 Adenosine 下载 G PROTEIN-COUPLED RECEPTORS 下载 IP3 receptor 下载 Adrenoceptors, a1 下载 Adrenoceptors, a2 下载 Adrenoceptors, β 下载 GABAA (γ-aminobutyric acid) 下载 GABAB 下载 Calcium (voltage-gated) 下载 Phosphodiesterases 下载 Phosphoinositide Kinases 下载 Phospholipase A2 下载 Phospholipase C 下载 Phospholipase D 下载 Phosphoprotein Phosphatases 下载 Platelet-Activating Factor Receptors 下载 Protein Prenyltransferases 下载 Steroids Receptors 下载 Protein tyrosine phosphatases 下载 G Proteins (Heterotrimeric) 下载 Caspases 下载 Nitric Oxide Synthases 下载 Nonsteroidal Receptors 下载 Peroxisome proliferator activated receptors 下载 Ryanodine Receptors 下载 Adenylyl Cyclase 下载 GTP Binding Proteins 下载 Adenosine 下载 G PROTEIN-COUPLED RECEPTORS 下载 IP3 receptor 下载 Adrenoceptors, a1 下载 Adrenoceptors, a2 下载 Adrenoceptors, β 下载 GABAA (γ-aminobutyric acid) 下载 GABAB 下载 Calcium (voltage-gated) 下载 Phosphodiesterases 下载 Phosphoinositide Kinases 下载 Phospholipase A2 下载 Phospholipase C 下载 Phospholipase D 下载 Phosphoprotein Phosphatases 下载 Platelet-Activating Factor Receptors 下载 Protein Prenyltransferases 下载 Steroids Receptors 下载 Protein tyrosine phosphatases 下载 G Proteins (Heterotrimeric) 下载 Caspases 下载 Nitric Oxide Synthases 下载 Nonsteroidal Receptors 下载 Peroxisome proliferator activated receptors 下载 Ryanodine Receptors 下载 Adenylyl Cyclase 下载 GTP Binding Proteins 下载