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Cyanine5 NHS ester
作者：德尔塔 日期：2022-09-27
During the last years, Cyanine5 (an analog of Cy5®) has become an incredibly popular label in life science research and diagnostics. The fluorophore has its emission maximum in the red region, where many CCD detectors exhibit maximum sensitivity, and biological objects show low background. The dye color is very intense, therefore quantities as small as 1 nmol can be detected in gel electrophoresis by naked eye.This Cyanine5 NHS ester (analog to Cy5® NHS ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires a small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reactions (please see our recommended protocol for more details). This reagent is ideal for very cost-efficient labeling of soluble proteins as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. For more sophisticated targets such as easily degradable proteins, when the use of DMF or DMSO is undesirable, consider using water-soluble sulfo-Cyanine 5 NHS ester which does not require any co-solvent, and features very similar fluorescent properties.Cyanine5 fluorophore is compatible with various instrumentation including many fluorescent microscopes, imagers, scanners, and fluorescence readers. A number of various Cyanine5 analogs exist - Cyanine5 NHS ester can replace activated esters of Cy5®, Alexa Fluor 647, and DyLight 649.During the last years, Cyanine5 (an analog of Cy5®) has become an incredibly popular label in life science research and diagnos
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Cyanine5 hydrazide
作者：德尔塔 日期：2022-09-27
Cyanine5 hydrazide is a reactive dye for the labeling of aldehydes and ketones, an analog of Cy5® hydrazide.This dye reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. Examples are proteins subjected to oxidative stress, glycosylated proteins pre-activated by periodate oxidation (including antobodies), and oligonucleotides with aldehyde moieties.Cyanine5 hydrazide replaces carbonyl-reactive Cy5®, Alexa Fluor 647, DyLight 649 dyes.Cyanine5 hydrazide is a reactive dye for the labeling of aldehydes and ketones, an analog of Cy5® hydrazide.This dye reacts smoothly and nearly quantitatively with various carbonyl groups encountered in biomolecules. Examples are proteins subjected to oxidative stress, glycosylated proteins pre-activated by periodate oxidation (including antobodies), and oligonucleotides with aldehyde moieties.Cyanine5 hydrazide replaces carbonyl-reactive Cy5®, Alexa Fluor 647, DyLight 649 dyes.Cas No. 1427705-31-4 SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C32H42Cl2N4O 分子量 569.61 溶解度 moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols) 储存条件 Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prol
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Cyanine5 DBCO
作者：德尔塔 日期：2022-09-27
A derivative of Cyanine5 red-emitting fluorophore possessing DBCO (dibenzocyclooctyne, also known as ADIBO, azodibenzocyclooctyne) group for copper free Click chemistry.Strained cycloalkynes, such as cyclooctynes, react with azides very rapidly in the absence of copper catalyst in a strain promoted alkyne azide cycloaddition (spAAC). This reaction is very fast, mild, and biocompatible.Compared to other cycloalkynes, DBCO provide among the fastest reaction kinetics, still possessing good stability.A derivative of Cyanine5 red-emitting fluorophore possessing DBCO (dibenzocyclooctyne, also known as ADIBO, azodibenzocyclooctyne) group for copper free Click chemistry.Strained cycloalkynes, such as cyclooctynes, react with azides very rapidly in the absence of copper catalyst in a strain promoted alkyne azide cycloaddition (spAAC). This reaction is very fast, mild, and biocompatible.Compared to other cycloalkynes, DBCO provide among the fastest reaction kinetics, still possessing good stability.Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C53H59N4F6O2P 分子量 929.03 溶解度 good in DMF, DMSO, chlorinated organic solvents, practically insoluble in water (
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Cyanine5 carboxylic acid
作者：德尔塔 日期：2022-09-27
Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.Cas No. 1032678-07-1 (chloride), 195867-59-5 (inner salt), 766503-38-2 (without anion) SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C32H39ClN2O2 分子量 519.12 溶解度 soluble in organic solvents (DMF, DMS
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Cyanine5 Boc-hydrazide
作者：德尔塔 日期：2022-09-27
Boc-protected Cyanine5 hydrazide reactive dye for the labeling of aldehydes and ketones.Boc- (tert-butoxycarbonyl) protective group can be removed with trifluoroacetic acid, or other strong acid. Reactive hydrazide is formed, which can then couple with various carbonyl groups yielding Cyanine5-labeled molecules.Boc-protected Cyanine5 hydrazide reactive dye for the labeling of aldehydes and ketones.Boc- (tert-butoxycarbonyl) protective group can be removed with trifluoroacetic acid, or other strong acid. Reactive hydrazide is formed, which can then couple with various carbonyl groups yielding Cyanine5-labeled molecules.Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C37H49ClN4O3 分子量 633.26 溶解度 good in dichloromethane, polar organic solvents (DMF, DMSO), alcohols, low in water 储存条件 Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice
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Cyanine5 azide
作者：德尔塔 日期：2022-09-27
Cyanine5 azide labeling reagent for Click Chemistry, available as 10 mM solution in DMSO, and in solid form.This azide is soluble in organic solvents (e.g. DMSO, DMF), therefore the labeling reaction should be carried out with a small amount of an organic co-solvent. This azide can be used for the labeling of alkyne-modified biomolecules in mixtures of water with organic solvents. The solution in DMSO is ready for use in bioconjugation. A water-soluble sulfonated version of this reagent is also available.Cyanine5 is an analog of Cy5®, one of the most commonly used fluorophores which is compatible with various instruments. Cyanine5 can also be used as a replacement for Alexa Fluor® 647, and DyLight® 649.Cyanine5 azide labeling reagent for Click Chemistry, available as 10 mM solution in DMSO, and in solid form.This azide is soluble in organic solvents (e.g. DMSO, DMF), therefore the labeling reaction should be carried out with a small amount of an organic co-solvent. This azide can be used for the labeling of alkyne-modified biomolecules in mixtures of water with organic solvents. The solution in DMSO is ready for use in bioconjugation. A water-soluble sulfonated version of this reagent is also available.Cyanine5 is an analog of Cy5®, one of the most commonly used fluorophores which is compatible with various instruments. Cyanine5 can also be used as a replacement for Alexa Fluor® 647, and DyLight® 649.Cas No. 1267539-32-1 (chloride) SDF 别名 N/A
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Cyanine5 amine
作者：德尔塔 日期：2022-09-27
Cyanine5 amine is a reactive dye which contains amino group, an analog of Cy5® amine. This reagent can be coupled with a variety of activated esters and other electrophilic reagents. For example, this amine can be coupled with EDC-activated carboxylic groups.This bright and photostable dye is suitable for many different methods of fluorescence detection. Colorful fluorophore can also be easily detected in small quantities (nanomols) by naked human eye.Cyanine5 amine is a reactive dye which contains amino group, an analog of Cy5® amine. This reagent can be coupled with a variety of activated esters and other electrophilic reagents. For example, this amine can be coupled with EDC-activated carboxylic groups.This bright and photostable dye is suitable for many different methods of fluorescence detection. Colorful fluorophore can also be easily detected in small quantities (nanomols) by naked human eye.Cas No. 1807529-70-9 SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C38H54Cl2N4O 分子量 653.77 溶解度 moderate solubility in water, good in polar organic solvents (DMF, DMSO, alcohols) 储存条件 Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light.
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Cyanine5 alkyne
作者：德尔塔 日期：2022-09-27
Cyanine5 alkyne for Click Chemistry, an analog of Cy5® alkyne. With this product, deeply colored, and photostable Cyanine5 fluorophore can be attached to various molecules via Click Chemistry reaction with azides.This alkyne is non-water soluble, but it can be dissolved in DMF or DMSO prior to reaction, and added to aqueous reaction mixture. With our labeling protocol, the labeling reaction is very efficient, and high-yielding.Various substrates bearing azides can be used for the labeling, including azido-labeled biomolecules, polymers, and solid surfaces.Cyanine5 alkyne for Click Chemistry, an analog of Cy5® alkyne. With this product, deeply colored, and photostable Cyanine5 fluorophore can be attached to various molecules via Click Chemistry reaction with azides.This alkyne is non-water soluble, but it can be dissolved in DMF or DMSO prior to reaction, and added to aqueous reaction mixture. With our labeling protocol, the labeling reaction is very efficient, and high-yielding.Various substrates bearing azides can be used for the labeling, including azido-labeled biomolecules, polymers, and solid surfaces.Cas No. 1223357-57-0 SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C35H42ClN3O 分子量 556.18 溶解度 good in dichloromethane, DMF, DMSO, alcohols, very poorly soluble in water (200 mg/L = 0.4 m
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Cyanine3.5 NHS ester
作者：德尔塔 日期：2022-09-27
Cyanine3.5 NHS ester (an analog of Cy3.5® NHS ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.Cyanine3.5 NHS ester can replace NHS esters of Cy3.5®, Alexa Fluor 594, DyLight 594.Cyanine3.5 NHS ester (an analog of Cy3.5® NHS ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.Cyanine3.5 NHS ester can replace NHS esters of Cy3.5®, Alexa Fluor 594, DyLight 594.Cas No. 2231670-85-0 SDF 别名 N/A 化学名 N/A Canonical SMILES N/A 分子式 C42H44N3BF4O4 分子量 741.62 溶解度 soluble in organic solvents (DMF, DMSO, dichloromethane), insoluble in water 储存条件 Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy7.5 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of amino-groups in biomolecules.Cy7.5 NHS ester is a NIR dye with low aqueous solubility and long-wave emission. This labeling reagent is amine-reactive derivative of this fluorophore. In vivo, near infrared radiation can be used for imaging applications for it readily penetrates tissues. This product can be used for the labeling of various biomolecules such as proteins and peptides which contain amine groups, to track their distribution in organism in vivo. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.In mice, Cy7.5 NHS ester labeled insulin (Cy7.5-INS) and were injected via subcutaneous injection at insulin dose of 1 IU/kg. The biodistribution of Cy7.5-Labeled insulin, INS/HTCC, and INS/HTCC-CA11 Nanoparticles was easily analyzed [1].Reference:[1] Zhang, Z. ; Cai, H.; Liu, Z.; Yao, P. Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative. Molecular Pharmaceutics, 2016, 13(7), 2433-2442.Cy7.5 NHS ester is a NIR dye with low aqueous solubility and long-wave emission. This labeling reagent is amine-reactive derivative of this fluorophore. In vivo, near infrared radiation can be used for imaging applications for it readily penetrates tissues. This product can be used for the labeling of various biomolecules such as proteins and pepti
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Cy7.5 maleimide(non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of cysteine residues, as well as other thiolated moleculesThiol-reactive, near infrared dye Cy7.5 for the labeling of protein SH groups.Most proteins contain sulfhydryl groups which can be selectively labeled with maleimides. With this reagent, these proteins can be converted to near infrared (NIR) fluorescent conjugates. After it, the conjugates can be used in non-invasive live organism imaging to study distribution of the protein in tissues and organs.Thiol-reactive, near infrared dye Cy7.5 for the labeling of protein SH groups.Most proteins contain sulfhydryl groups which can be selectively labeled with maleimides. With this reagent, these proteins can be converted to near infrared (NIR) fluorescent conjugates. After it, the conjugates can be used in non-invasive live organism imaging to study distribution of the protein in tissues and organs.Cas No. N/A SDF 别名 N/A 化学名 6-[(2E)-1,1-dimethyl-2-[(2E)-2-[3-[(E)-2-(1,1,3-trimethylbenzo[e]indol-3-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]benzo[e]indol-3-yl]-N-[2-(2,5-dioxopyrrol-1-yl)ethyl]hexanamide Canonical SMILES CC1(C(=[N+](C2=C1C3=CC=CC=C3C=C2)C)C=CC4=CC(=CC=C5C(C6=C(N5CCCCCC(=O)NCCN7C(=O)C=CC7=O)C=CC8=CC=CC=C86)(C)C)CCC4)C 分子式 C51H55ClN4O3 分子量 807.46 溶解度 soluble in organic solvents (DMSO, DMF, dichloromethane), low
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Cy7.5 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy7.5 carboxylic acid is a free un-activated NIR dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In mice, near-infrared labeling of the materials allowed for non-invasive imaging of the injected hydrogel. Cy7.5 carboxylic acid labeled images can demonstrate localization of the injected hydrogel to the affected kidney. Moreover, the methodology allowed direct quantification of material degradation in vivo [1].Reference:[1]. Rodell, C.B.; Rai, R.; Faubel, S.; Burdick, J.A.; Soranno, D.E. Local Immunotherapy via Delivery of Interleukin-10 and Transforming Growth Factor β Antagonist for Treatment of Chronic Kidney Disease. Journal of Controlled Release, 2015, 206, 131–139.Cy7.5 carboxylic acid is a free un-activated NIR dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent
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Cy7.5 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesCy7.5 azide a NIR fluorescence dye that ready for the use in Click Chemistry labeling with long-wave infrared fluorescence. For other fluorescent applications, especially requiring low fluorescent background, this labeling reagent was also popular used. As generic Click Chemistry labeling protocol, azide is available as DMSO solution. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cy7.5 azide a sulfonated dye with absorption peaks at 773 and 808 nm, can be the optimal fluorescent probe that should have separate absorption spectra. The changes in the absorption and scattering properties of the tissue are negligible in the range of 750 to 850 nm [1].Reference:[1] Osnat Harbater,Israel Gannot. Fluorescent probes concentration estimation in vitro and ex vivo as a model for early detection of Alzheimer’s disease.Jornal of biomedical optics. 2014.19(12).Cy7.5 azide a NIR fluorescence dye that ready for the use in Click Chemistry labeling with long-wave infrared fluorescence. For other fluorescent applications, especially requiring low fluorescent background, this labeling reagent was also popular used. As generic Click Chemistry labeling protocol, azide is available as DMSO solution. For biomolecule labeling, the labeling reagent has low aqueous solubility, using o
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Cy7.5
作者：德尔塔 日期：2022-09-26
Cy7.5 是一种荧光标记试剂 (Ex=700-770 nm，Em=790 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽，寡聚核苷酸等。Cy7.5 is a fluorescence imaging (FI) agent (Ex=700-770 nm，Em=790 nm) as well as a magnetic resonance imaging (MRI) imaging agent. Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotide[1].[1]. Zhan Y, et al. In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles. Molecules. 2017 Dec 12;22(12). pii: E2208.Cy7.5 is a fluorescence imaging (FI) agent (Ex=700-770 nm，Em=790 nm) as well as a magnetic resonance imaging (MRI) imaging agent. Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotide[1].[1]. Zhan Y, et al. In Vivo Dual-Modality Fluorescence and Magnetic Resonance Imaging-Guided Lymph Node Mapping with Good Biocompatibility Manganese Oxide Nanoparticles. Molecules. 2017 Dec 12;22(12). pii: E2208.Cas No. 847180-48-7 SDF 别名 N/A 化学名 N/A Canonical SMILES O=S(C1=CC(S(=O)(O)=O)=C2C(C3=C([N+](CC)=C(/C=C/C=C/C=C/C=C4N(CCCCCC(O)=O)C5=C(C6=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C6C=C5)C/4(C)C)C3(C)C)C=C2)=C1)([O-])=O 分子式 C43H46N2O14S4 分子量 943.09 溶解度 Soluble in DMSO 储存条件 Store at -20°C, protect from light
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Cy7-YNE
作者：德尔塔 日期：2022-09-26
Cy7-YNE 是一种荧光标记试剂 (Ex=700-770 nm，Em=790 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽等。Cy7-YNE is a fluorescence labeling agent (Ex=700-770 nm，Em=790 nm). Cyanine dyes are used to label proteins, antibodies, and peptides.Cy7-YNE is a fluorescence labeling agent (Ex=700-770 nm，Em=790 nm). Cyanine dyes are used to label proteins, antibodies, and peptides.Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CC1(C)C(/C=C/C=C/C=C/C=C2N(CCCCCC(NCC#C)=O)C(C=CC(S(=O)(O)=O)=C3)=C3C\2(C)C)=[N+](CC)C4=CC=C(S(=O)([O-])=O)C=C41 分子式 C38H45N3O7S2 分子量 719.91 溶解度 Soluble in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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