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CAS:1426174-41-5|Ezetimibe phenoxy glucuronide-d4，Ezetimibe glucuronide-d4; Ezetimibe β-D-glucuronide-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].体内研究(In Vivo)After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：589.57Formula：C30H25D4F2NO9CAS 号：1426174-41-5非标记 CAS：190448-57-8性状：固体颜色：White to off-white中文名称：依泽替米贝葡糖苷酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [Content Brief][2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
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CAS:2043026-13-5|Roxadustat-d5，罗沙司他-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Roxadustat-d5 相关抗体:Ferritin Heavy Chain AntibodyHIF1 alpha AntibodyHIF1 beta AntibodyAMID/FSP1 AntibodyPeroxiredoxin 1 Antibody (YA692)PRDX3 Antibody (YA909)HIF 2 alpha AntibodyCA9 Antibody (YA1368)HIF2 alpha Antibody (YA1445)ORP150 Antibody (YA1478)PHD3 Antibody (YA1612)CITED2 Antibody (YA2596)Ferritin Light Chain Antibody (YA971)Ferritin Light Chain Antibody (YA972)ORP1 Antibody (YA1477)HIF1AN Antibody (YA1907)OS9 Antibody (YA1939)PHD2 Antibody (YA2431)HIF Prolyl Hydroxylases Antibody (YA2975)HLF Antibody (YA2990)PHD1 Antibody (YA3325)分子量：357.37Formula：C19H11D5N2O5CAS 号：2043026-13-5非标记 CAS：808118-40-3性状：固体颜色：White to off-white中文名称：罗沙司他-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： ≥98.0%
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CAS:127685-38-5|Cholesterol-5α,6α-epoxide-d7
作者：德尔塔生物 日期：2025-07-08
生物活性：Cholesterol-5α,6α-epoxide-d7 is deuterium labeled Cholesterol-5α,6α-epoxide.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：409.70Formula：C27H39D7O2CAS 号：127685-38-5非标记 CAS：1250-95-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度： 99.3%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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CAS:1093851-63-8|Oseltamivir-d5，奥司他韦-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oseltamivir-d5 相关抗体:Poliovirus Receptor Antibody (YA2556)分子量：317.44Formula：C16H23D5N2O4CAS 号：1093851-63-8非标记 CAS：196618-13-0中文名称：奥司他韦-d5； 奥斯他韦-d5； 奥司他伟-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]
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CAS:1217686-14-0|4-Hydroxyatomoxetine-d3，托莫西汀杂质24-d3
作者：德尔塔生物 日期：2025-07-08
生物活性：4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor[1].分子量：274.37Formula：C17H18D3NO2CAS 号：1217686-14-0非标记 CAS：435293-66-6性状：固体颜色：Light yellow to yellow中文名称：托莫西汀杂质24-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1185179-33-2|Acyclovir-d4，Aciclovir-d4; Acycloguanosine-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Acyclovir-d4 is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Acyclovir-d4 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子
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CAS:1093659-89-2|Ezetimibe-d4-1，依泽替米贝-d4; SCH 58235-d4-1
作者：德尔塔生物 日期：2025-07-08
生物活性：Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ezetimibe-d4-1 相关抗体:PGK1 AntibodyKeap1 AntibodyPhospho-Nrf2 (Ser40) Antibody (YA169)Phospho-Nrf2 (Ser40) Antibody (YA168)PGK1 Antibody (YA862)GCLC Antibody (YA2898)GCLM Antibody (YA1407)分子量：413.45Formula：C24H17D4F2NO3CAS 号：1093659-89-2非标记 CAS：163222-33-1性状：固体颜色：White to off-white中文名称：依泽替米贝-d4-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1217785-83-5|Posaconazole-d5，SCH 56592-d5
作者：德尔塔生物 日期：2025-07-08
生物活性：Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].分子量：705.81Formula：C37H37D5F2N8O4CAS 号：1217785-83-5非标记 CAS：171228-49-2性状：固体颜色：Off-white to light yellow中文名称：泊沙康唑 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1219803-84-5|Cetirizine-d4，左西替利嗪-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Cetirizine-d4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].IC50 & Target：H1 Receptor分子量：392.91Formula：C21H21D4ClN2O3CAS 号：1219803-84-5非标记 CAS：83881-52-1性状：固体颜色：White to off-white中文名称：左西替利嗪-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1420880-41-6|Olmesartan-d4，奥美沙坦 D4; RNH-6270-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Olmesartan-d4 is the deuterium labeled Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.IC50 & Target：AT1 Receptor分子量：450.53Formula：C24H22D4N6O3CAS 号：1420880-41-6非标记 CAS：144689-24-7性状：固体颜色：Off-white to light yellow中文名称：奥美沙坦 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1308278-50-3|Cariprazine-d8，RGH-188 d8
作者：德尔塔生物 日期：2025-07-08
生物活性：Cariprazine-d8 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).IC50 & Target：D3 Receptor分子量：435.46Formula：C21H24D8Cl2N4OCAS 号：1308278-50-3非标记 CAS：839712-12-8性状：固体颜色：White to off-white中文名称：卡利拉嗪 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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CAS:97781-16-3|Aspirin-d4，Acetylsalicylic Acid-d4; ASA-d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Aspirin-d4 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Aspirin-d4 相关抗体:S100A10 Antibody (YA675)COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：184.18Formula：C9H4D4O4CAS 号：97781-16-3非标记 CAS：50-78-2性状：固体颜色：White to off-white中文名称：阿司匹林 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1356841-72-9|Tetrahydrofolic acid-d4，四氢叶酸 d4
作者：德尔塔生物 日期：2025-07-08
生物活性：Tetrahydrofolic acid-d4 is the deuterium labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Tetrahydrofolic acid-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：449.45Formula：C19H19D4N7O6CAS 号：1356841-72-9非标记 CAS：135-16-0中文名称：四氢叶酸 d4运输条件
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CAS:1261393-77-4|Amiodarone-d10 hydrochloride，胺碘酮-d10
作者：德尔塔生物 日期：2025-07-08
生物活性：Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Amiodarone-d10 hydrochloride 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：691.83Formula：C25H20D10ClI2NO3CAS 号：1261393-77-4非标记 CAS：1951-25-3性状：固体颜色：Light yellow to yellow中文名称：胺碘酮-d10；乙碘酮-d10；安律酮-d10；胺碘达隆-d10；胺碘呋酮-d10；乙胺碘呋酮-d10运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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CAS:201612-55-7|2-Deoxy-D-glucose-13C，2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C
作者：德尔塔生物 日期：2025-07-08
生物活性：2-Deoxy-D-glucose-13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2-Deoxy-D-glucose-13C 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：165.15Formula：C513CH12O5CAS 号：201612-55-7非标记 CAS：154-17-6性状：固体颜色：White to off-white中文名称：2-脱氧-D-葡萄糖 13C运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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