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CAS:15681-89-7|Sodium borodeuteride-d4

CAS:15681-89-7|Sodium borodeuteride-d4

作者:德尔塔生物 日期:2025-06-10

生物活性:Sodium borodeuteride-d4 is the deuterium labeled Sodium borodeuteride[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sodium borodeuteride-d4 相关抗体:CD161 AntibodyBrdU Antibody (YA578)CD99 AntibodyCD44 AntibodyDYKDDDDK Tag (FLAG) AntibodyGFP AntibodyMyc-tag AntibodyFerritin Heavy Chain Antibody53BP1 AntibodyCD9 Antibody (YA524)METTL3 AntibodyNeuN Antibodyp27 KIP 1 AntibodyUbiquitin Antibody (YA022)Beta Tubulin AntibodySQSTM1/p62 Antibody (YA669)TGF beta 1 AntibodyCD45 Antibody (YA800)CD63 AntibodyCD81 AntibodyCD86 AntibodyCD9 Antibodyp38 AntibodySQSTM1/p62 Antibody (YA062)xCT Antibody (YA006)CD40 AntibodyCD40L AntibodyCD42a AntibodyCD45 Antibody (YA533)CD47 Antibody分子量:41.86Formula:BD4NaCAS 号:15681-89-7非标记 CAS:16940-66-2性状:固体颜色:White to off-white运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Store at room temperature, keep dry and coolIn solvent:-80°C:2 years-20°C:1 year纯度 & 产品资料Data Sheet (519 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

CAS:1794754-60-1|Telmisartan-d7,BIBR 277-d7

CAS:1794754-60-1|Telmisartan-d7,BIBR 277-d7

作者:德尔塔生物 日期:2025-06-10

生物活性:Telmisartan-d7 (BIBR 277-d7) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Telmisartan-d7 相关抗体:Natriuretic Peptides A Antibody (YA1381)Angiotensinogen Antibody (YA2097)Natriuretic Peptides B Antibody (YA999)Natriuretic Peptides B Antibody (YA1000)Natriuretic Peptides B Antibody (YA1001)AGTR2 Antibody (YA3090)Angiotensin II Type 1 Receptor Antibody (YA3358)分子量:521.66Formula:C33H23D7N4O2CAS 号:1794754-60-1非标记 CAS:144701-48-4中文名称:替米沙坦 d4-d7运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (544 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief][2]. Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302(3):1089-95. [Content Brief][3]. Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor sup

CAS:1014689-17-8|Sudan III-d6,苏丹红Ⅲ-d6; Sudan Red III-d6;  Tetrazobenzene-β-naphthol-d6;  111440 Red-d6

CAS:1014689-17-8|Sudan III-d6,苏丹红Ⅲ-d6; Sudan Red III-d6; Tetrazobenzene-β-naphthol-d6; 111440 Red-d6

作者:德尔塔生物 日期:2025-06-10

生物活性:Sudan III-d6 (Sudan Red III-d6; Tetrazobenzene-β-naphthol-d6) is a deuterium labeled Sudan III (HY-D0931). Sudan III is a hydrophobic bisazo dye[1][2].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sudan III-d6 相关抗体:Firefly Luciferase Antibody (YA1495)Renilla Luciferase Antibody (YA3013)Malachite green Antibody (Biotin) (YA902)Sudan I Antibody (YA905)分子量:358.43Formula:C22H10D6N4OCAS 号:1014689-17-8非标记 CAS:85-86-9性状:固体颜色:White to off-white中文名称:苏丹红Ⅲ-d6;苏丹红3号-d6;苏丹红三号-d6运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month纯度 & 产品资料纯度: 93.04%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief][2]. Sakurai T, et al. Color Change of Sudan III against Concentrated Sulfuric Acid in Acetonitrile and Quantification for a Small Amount of Concentrated Sulfuric Acid. Anal Sci. 2016;32(2):129-33. [Content Brief]

CAS:688302-31-0|Pyridoxine-d5,吡哆醇-d5; Pyridoxol-d5

CAS:688302-31-0|Pyridoxine-d5,吡哆醇-d5; Pyridoxol-d5

作者:德尔塔生物 日期:2025-06-10

生物活性:Pyridoxine-d5 (Pyridoxol-d5) is a deuterium labeled Pyridoxine (HY-B1328). Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pyridoxine-d5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)PGK1 AntibodyGAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyKeap1 AntibodyPhospho-Nrf2 (Ser40) Antibody (YA169)TSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyPhospho-Nrf2 (Ser40) Antibody (YA168)Heme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)分子量:174.21Formula:C8H6D5NO3CAS 号:688302-31-0非标记 CAS:65-23-6性状:固体颜色:White to off-white中文名称:吡哆醇-d5; 维生素B6-d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

CAS:1246816-14-7|Melamine-15N3,13C3,三聚氰胺-13C3,15N1

CAS:1246816-14-7|Melamine-15N3,13C3,三聚氰胺-13C3,15N1

作者:德尔塔生物 日期:2025-06-10

生物活性:Melamine-15N3,13C3 is a 13C- and 15N-labeled Melamine (HY-Y1117). Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials[1][2].体外研究(In Vitro):氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Melamine-15N3,13C3 相关抗体:FMO3 Antibody (YA1992)分子量:132.08Formula:13C3H6N315N3CAS 号:1246816-14-7非标记 CAS:108-78-1性状:固体颜色:White to off-white中文名称:三聚氰胺-13C3,15N3;密胺-13C3,15N3;三聚氰酰胺-13C3,15N3运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度: 96.08%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief][2]. Melamine

CAS:2714316-71-7|Zuclomiphene-d4 citrate

CAS:2714316-71-7|Zuclomiphene-d4 citrate

作者:德尔塔生物 日期:2025-06-10

生物活性:Zuclomiphene-d4 (citrate) is a deuterium labeled Zuclomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4].分子量:602.11Formula:C32H32D4ClNO8CAS 号:2714316-71-7非标记 CAS:7619-53-6性状:固体颜色:White to off-white运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

CAS:2070009-63-9|Ivabradine-d6 hydrochloride,盐酸伊伐布雷定 D6

CAS:2070009-63-9|Ivabradine-d6 hydrochloride,盐酸伊伐布雷定 D6

作者:德尔塔生物 日期:2025-06-10

生物活性:Ivabradine-d6 (hydrochloride) is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.分子量:511.08Formula:C27H31D6ClN2O5CAS 号:2070009-63-9非标记 CAS:148849-67-6性状:固体颜色:White to off-white中文名称:盐酸伊伐布雷定 d6 (盐酸盐)运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:1185995-18-9|Pentoxifylline-d5,BL-191-d5; PTX-d5; Oxpentifylline-d5

CAS:1185995-18-9|Pentoxifylline-d5,BL-191-d5; PTX-d5; Oxpentifylline-d5

作者:德尔塔生物 日期:2025-06-10

生物活性:Pentoxifylline-d5 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pentoxifylline-d5 相关抗体:CD4 AntibodyTARBP2 Antibody (YA1433)SAMHD1 Antibody (YA1542)PDE1B Antibody (YA1553)PDE4B Antibody (YA2932)PDE2A Antibody (YA2989)SV40 T Antigen Antibody (YA3256)CLEC12A Antibody (YA1419)PDE4D Antibody (YA1714)Tat SF1 Antibody (YA2886)分子量:283.34Formula:C13H13D5N4O3CAS 号:1185995-18-9非标记 CAS:6493-05-6性状:固体颜色:White to off-white中文名称:己酮可可碱 d5运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:557794-38-4|Dapsone-d8,4,4′-Diaminodiphenyl sulfone-d8; DDS-d8

CAS:557794-38-4|Dapsone-d8,4,4′-Diaminodiphenyl sulfone-d8; DDS-d8

作者:德尔塔生物 日期:2025-06-10

生物活性:Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].体外研究(In Vitro):氨苯砜 (0.06 mM; 30 min) 抑制 N-Formyl-Met-Leu-Phe.html" class="link-product" target="_blank">N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) 和生理激动剂 C5a (100 nM) 触发的细胞内外超氧化物 (O2-) 和胰蛋白酶 E 的释放,而不是对 Phorbol 12-myristate 13-acetate.html" class="link-product" target="_blank">Phorbol 12-myristate 13-acetate (HY-18739) (100 nM) 没有作用[5]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Dapsone-d8 相关抗体:Catalase Antibody (YA552)Catalase Antibody (YA811)MRP2 AntibodyC Reactive Protein Antibody (YA941)Elongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)PARK7/DJ1 Antibody (YA1799)Sulfadimidine Antibody (YA906)C Reactive Protein Antibody (YA939)C Reactive Protein Antibody (YA940)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)PON1 Antibody (YA1666)PON2 Antibody (YA1688)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Anti

CAS:1189649-47-5|Oxprenolol-d7 hydrochloride,Ba 39089-d7

CAS:1189649-47-5|Oxprenolol-d7 hydrochloride,Ba 39089-d7

作者:德尔塔生物 日期:2025-06-10

生物活性:Oxprenolol-d7 (hydrochloride) is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oxprenolol-d7 hydrochloride 相关抗体:ADRB2 AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量:308.85Formula:C15H17D7ClNO3CAS 号:1189649-47-5非标记 CAS:6452-73-9性状:固体颜色:White to off-white中文名称:盐酸氧烯洛尔 d7 (盐酸盐)运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:203784-52-5|Nortriptyline-d3 hydrochloride,Desmethylamitriptyline-d3 (hydrochloride; Desitriptilina-d3 (hydrochloride

CAS:203784-52-5|Nortriptyline-d3 hydrochloride,Desmethylamitriptyline-d3 (hydrochloride; Desitriptilina-d3 (hydrochloride

作者:德尔塔生物 日期:2025-06-10

生物活性:Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Nortriptyline-d3 hydrochloride 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量:302.86Formula:C19H19D3ClNCAS 号:203784-52-5非标记 CAS:894-71-3性状:固体颜色:White to off-white中文名称:盐酸去甲替林 d3 (盐酸盐)运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, sealed storage, away from moisture

CAS:64717-35-7|Propantheline-d3 bromide,普鲁本辛 d3 (溴盐

CAS:64717-35-7|Propantheline-d3 bromide,普鲁本辛 d3 (溴盐

作者:德尔塔生物 日期:2025-06-10

生物活性:Propantheline-d3 (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Propantheline-d3 bromide 相关抗体:Muscarinic Acetylcholine receptor M3 AntibodyMuscarinic Acetylcholine Receptor M2 Antibody (YA2610)分子量:451.41Formula:C23H27D3BrNO3CAS 号:64717-35-7非标记 CAS:50-34-0性状:固体颜色:Off-white to light yellow中文名称:普鲁本辛 d3 (溴盐)运输条件:Room temperature in continental US; may vary elsewhere.储存方式:4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

CAS:1185117-79-6|Climbazole-d4,BAY-e 6975-d4

CAS:1185117-79-6|Climbazole-d4,BAY-e 6975-d4

作者:德尔塔生物 日期:2025-06-10

生物活性:Climbazole-d4 is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450[2].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Climbazole-d4 相关抗体:SDHA Antibody分子量:296.79Formula:C15H13D4ClN2O2CAS 号:1185117-79-6非标记 CAS:38083-17-9性状:固体颜色:White to off-white中文名称:氯咪巴唑 d4运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:94513-92-5|Nadolol-d9,纳多洛尔 D9; SQ-11725-d9

CAS:94513-92-5|Nadolol-d9,纳多洛尔 D9; SQ-11725-d9

作者:德尔塔生物 日期:2025-06-10

生物活性:Nadolol-d9 is the deuterium labeled Nadolol. Nadolol is a non-selective and orally active β-adrenergic receptors blocker[1].分子量:318.46Formula:C17H18D9NO4CAS 号:94513-92-5非标记 CAS:42200-33-9性状:固体颜色:Off-white to light yellow中文名称:纳多洛尔 d9运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 years,4°C:2 yearsIn solvent:-80°C:6 months,-20°C:1 month

CAS:1185039-30-8|Gliclazide-d4,格列齐特 d4

CAS:1185039-30-8|Gliclazide-d4,格列齐特 d4

作者:德尔塔生物 日期:2025-06-10

生物活性:Gliclazide-d4 (S1702 D4) is the deuterium labeled Gliclazide. Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic[1].体外研究(In Vitro):Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Gliclazide-d4 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量:327.44Formula:C15H17D4N3O3SCAS 号:1185039-30-8非标记 CAS:21187-98-4性状:固体颜色:White to off-white中文名称:格列齐特 d4运输条件:Room temperature in continental US; may vary elsewhere.储存方式:Powder:-20°C:3 yearsIn solvent:-80°C:6 months,-20°C:1 month