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Phytanic acid-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Phytanic acid-d3 is the deuterium labeled Phytanic acid[1]. Phytanic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata and Infantile Refsum Disease[2][3][4][5][6].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Phytanic acid-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：315.55Formula：C20H37D3O2CAS 号：1383920-40-8非标记 CAS：14721-66-5性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Solution, -20°C, 2 years纯度 & 产
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Carbon-13C，多壁碳纳米管(工业级-13C「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Carbon-13C is the 13C labeled Carbon[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：13.00Formula：13CCAS 号：14762-74-4性状：固体颜色：Dark gray to black中文名称：多壁碳纳米管(工业级)-13C运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料纯度： 97.10%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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Ethyl acetoacetate-d3，乙酰乙酸乙酯-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Ethyl acetoacetate-d3 is the deuterium labeled Ethyl acetoacetate. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[1][2][3]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[5].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ethyl acetoacetate-d3 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：133.16Formula：C6H7D3O3CAS 号：1565868-21-4性状：液体颜色：Colorless to light yellow中文名称：乙酰乙酸乙酯-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Butylated hydroxytoluene-d3，2,6-二叔丁基对甲酚-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Butylated hydroxytoluene-d3 is the deuterium labeled Butylated hydroxytoluene[1]. Butylated hydroxytoluene is an antioxidant widely used in foods and in food-related products[2]. Butylated hydroxytoluene is a Ferroptosis inhibitor[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Butylated hydroxytoluene-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyAMID/FSP1 AntibodyKi67 Antibody (YA001)Osteopontin AntibodyPeroxiredoxin 1 Antibody (YA692)分子量：223.37Formula：C15H21D3OCAS 号：86819-59-2性状：固体颜色：White to yellow中文名称：2,6-二叔丁基对甲酚-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Levoglucosan-d7，1,6-Anhydro-β-D-glucopyranose-d7; 1,6-Anhydro-β-D-glucose-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Levoglucosan-d7 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：169.18Formula：C6H3D7O5CAS 号：2483832-05-7性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Deucravacitinib，BMS-986165「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis[1][2].IC50 & Target[1]：Tyk2 JH2：0.2 nM (IC50)，JAK1 JH2：1 nM (IC50)体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。氘代化合物的潜在优势：(1) 延长半衰期体内。氘代化合物可能能够延长化合物的药代动力学特征，即延长体内半衰期。这可以提高化合物的安全性、功效和耐受性，并增加给药的便利性。(2) 提高口服生物利用度。氘化化合物可以降低肠壁和肝脏中不需要的代谢 (首过代谢) 的程度，使更大比例的未代谢药物到达其作用靶点。高生物利用度决定了它在低剂量下的活性和更好的耐受性。(3) 改善代谢特性。氘代化合物可以减少有毒或反应性代谢物的形成并改善药物代谢。(四) 提高用药安全性。氘代化合物可以减少或消除药物化合物的不良副作用并且是安全的。(5) 保持疗效。在先前的研究中，预计氘代化合物将保留与氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Deucravacitinib 相关抗体:IL-1 beta AntibodyPhospho-JAK2 (Tyr1007/1008) AntibodyJAK1 Antibody (YA722)EpCAM Antibody (YA772)JAK1 AntibodyJAK2 Antibody (YA721)Phospho-JAK2 (Tyr1007+Tyr1008) Antibod
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CAS:1977511-05-9|(+-Tetrabenazine-d6，(+-丁苯那嗪 d6
作者：德尔塔生物 日期：2025-08-13
生物活性：(+)-Tetrabenazine-d6 is the deuterium labeled (+)-Tetrabenazine. (+)-Tetrabenazine is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2).分子量：323.46Formula：C19H21D6NO3CAS 号：1977511-05-9非标记 CAS：58-46-8中文名称：(+)-丁苯那嗪 d6； (+)-丁苯喹嗪 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2. US20160222008A1.
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CAS:1562067-05-3|Banoxantrone-d12，AQ4N d12
作者：德尔塔生物 日期：2025-08-13
生物活性：Banoxantrone-d12 is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.分子量：456.55Formula：C22H16D12N4O6CAS 号：1562067-05-3非标记 CAS：136470-65-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (501 KB)产品使用指南 (1538 KB)
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CAS:1562066-98-1|Banoxantrone-d12 dihydrochloride，AQ4N-d12 dihydrochloride
作者：德尔塔生物 日期：2025-08-13
生物活性：Banoxantrone-d12 (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.分子量：529.48Formula：C22H18D12Cl2N4O6CAS 号：1562066-98-1非标记 CAS：252979-56-9性状：固体颜色：White to blue运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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CAS:1246818-14-3|Propiconazole-d7
作者：德尔塔生物 日期：2025-08-13
生物活性：Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Propiconazole-d7 相关抗体:Catalase Antibody (YA552)Catalase Antibody (YA811)SDHA AntibodyC Reactive Protein Antibody (YA941)PARK7/DJ1 Antibody (YA1799)C Reactive Protein Antibody (YA939)C Reactive Protein Antibody (YA940)PON1 Antibody (YA1666)PON2 Antibody (YA1688)分子量：349.26Formula：C15H10D7Cl2N3O2CAS 号：1246818-14-3非标记 CAS：60207-90-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (547 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokine
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CAS:1329836-90-9|Pravastatin-d3 sodium
作者：德尔塔生物 日期：2025-08-13
生物活性：Pravastatin-d3 (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pravastatin-d3 sodium 相关抗体:HMGCS2 AntibodyHMGB1 AntibodyHMGCR AntibodyBaf180 Antibody (YA1176)BANF1 Antibody (YA1740)LEF1 Antibody (YA3164)HMGA1 Antibody (YA1185)HMGA2 Antibody (YA1186)Baf57 Antibody (YA2110)HMGN2 Antibody (YA2839)HMG4 Antibody (YA2992)HMGB2 Antibody (YA2995)HMGCL Antibody (YA3024)分子量：449.53Formula：C23H32D3NaO7CAS 号：1329836-90-9非标记 CAS：81131-70-6性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Store at room temperature, keep dry and coolIn solvent：-80°C：2 years-20°C：1 year纯度 & 产品资料纯度： 99.02%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. [Content Brief]
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CAS:1304096-50-1|PLX-4720-d7
作者：德尔塔生物 日期：2025-08-13
生物活性：PLX-4720-d7 is the deuterium labeled PLX-4720. PLX-4720 is a potent and selective inhibitor of B-RafV600E with an IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.PLX-4720-d7 相关抗体:BRAF AntibodyPhospho-BRAF (Thr401) AntibodyA-RAF AntibodyB-Raf AntibodyRaf1 AntibodyRKIP Antibody (YA1869)A RAF Antibody (YA2673)分子量：420.87Formula：C17H7D7ClF2N3O3SCAS 号：1304096-50-1非标记 CAS：918505-84-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Tsai J, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A, 2008, 105(8), 3041-3046. [Content Brief][3]. Paraiso KH, et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the sup
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CAS:1216885-36-7|Fmoc-Aib-OH-d3
作者：德尔塔生物 日期：2025-08-13
生物活性：Fmoc-Aib-OH-d3 is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：328.38Formula：C19H16D3NO4CAS 号：1216885-36-7非标记 CAS：94744-50-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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CAS:1217720-20-1|rel-Ritonavir-d6，利托那韦-d6; rel-ABT 538-d6; rel-RTV-d6
作者：德尔塔生物 日期：2025-08-13
生物活性：rel-Ritonavir-d6 (rel-ABT 538-d6) is the deuterium labeled rel-Ritonavir. rel-Ritonavir is a relative configuration of Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to study of HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。 氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：726.98Formula：C37H42D6N6O5S2CAS 号：1217720-20-1非标记 CAS：155213-67-5性状：固体颜色：Off-white to light yellow中文名称：rel-利托那韦-d6；rel-瑞托纳韦-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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CAS:1217675-13-2|Lubiprostone-d7，RU-0211-d7; SPI-0211-d7
作者：德尔塔生物 日期：2025-08-13
生物活性：Lubiprostone-d7 (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Lubiprostone-d7 相关抗体:GPX4 AntibodyiNOS AntibodyTNF alpha AntibodyGlutathione Peroxidase 4 AntibodyTNF Receptor 2 AntibodyCD40 AntibodyCD40L AntibodyDR5 AntibodyGPX1 AntibodynNOS AntibodyGlutathione Peroxidase 1 Antibody (YA404)Calumenin Antibody (YA813)eNOS AntibodyPhospho-eNOS (Ser1177) AntibodyMPO AntibodyDDAH2 Antibody (YA1447)TNFAIP3 Antibody (YA2231)TRADD Antibody (YA2276)DcR2 Antibody (YA2588)TNFRSF10B Antibody (YA660)Anoctamin 1 Antibody4-1BB Ligand Antibody (YA1329)GITR Antibody (YA1333)BAFFR Antibody (YA1356)BCMA Antibody (YA1501)4-1BB Antibody (YA1506)TNFSF12 Antibody (YA1507)BAFF Antibody (YA1510)LIGHT Antibody (YA1512)GITR-L Antibody (YA1515)分子量：397.51Formula：C20H25D7F2O5CAS 号：1217675-13-2非标记 CAS：136790-76-6中文名称：鲁比前列酮 d7
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