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CY7-SE triethylamine
作者：德尔塔 日期：2022-09-26
CY7-SE triethylamine (Sulfo-Cyanine7 Succinimidyl Ester triethylamine) 是一种荧光标记试剂 (Ex=700-770 nm，Em=790 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽，寡聚核苷酸等。CY7-SE triethylamine (Sulfo-Cyanine7 Succinimidyl Ester triethylamine) is a fluorescence labeling agent (Ex=700-770 nm，Em=790 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides.CY7-SE triethylamine (Sulfo-Cyanine7 Succinimidyl Ester triethylamine) is a fluorescence labeling agent (Ex=700-770 nm，Em=790 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides.Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CCN(CC)CC.CC(/C(N1CCCCCC(ON2C(CCC2=O)=O)=O)=C\C=C\C=C\C=C\C3=[N+](CC)C(C=CC(S(=O)([O-])=O)=C4)=C4C3(C)C)(C)C5=C1C=CC(S(=O)(O)=O)=C5 分子式 C45H60N4O10S2 分子量 881.11 溶解度 Soluble in DMSO 储存条件 Store at -20°C,unstable in solution, ready to use. General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue i
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CY7-SE
作者：德尔塔 日期：2022-09-26
Cy7-SE被广泛用于标记肽，蛋白质和寡核苷酸等。激发波长(nm):749,发射波长(nm):767.Cy7-SE dyes are widely used for labeling peptides, proteins and oligos etc. Cy7-SE dye conjugates are one type of the most common near infrared red fluorophores used in in vivo imaging applications. Excitation (nm): 749, Emission (nm): 767Cy7-SE dyes are widely used for labeling peptides, proteins and oligos etc. Cy7-SE dye conjugates are one type of the most common near infrared red fluorophores used in in vivo imaging applications. Excitation (nm): 749, Emission (nm): 767Cas No. 477908-53-5 SDF 别名 N/A 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(ON2C(CCC2=O)=O)=O)=C\C=C\C=C\C=C\C3=[N+](CC)C(C=CC(S(=O)([O-])=O)=C4)=C4C3(C)C)(C)C5=C1C=CC(S(=O)(O)=O)=C5 分子式 C39H45N3O10S2 分子量 779.92 溶解度 DMSO : ≥ 41 mg/mL (52.57 mM) 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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CY7-N3
作者：德尔塔 日期：2022-09-26
CY7-N3 (Sulfo-Cyanine7-N3) 是一种用于点击化学的水溶NIR azide染料。CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble NIR dye azide for Click Chemistry.CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble NIR dye azide for Click Chemistry.Cas No. N/A SDF 别名 N/A 化学名 N/A Canonical SMILES CC1(C)C(/C=C/C=C/C=C/C=C2N(CCCCCC(NCCCN=[N+]=[N-])=O)C(C=CC(S(=O)(O)=O)=C3)=C3C\2(C)C)=[N+]([CH+]C)C4=CC=C(S(=O)([O-])=[O-])C=C41 分子式 C38H47N6O7S2 分子量 763.95 溶解度 Soluble in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy7 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of amino-groups in biomolecules.Cy7 NHS ester, also called Cy7 monofunctional N-hydroxysuccinimide ester or Cy7-NHS [1], is a near-infrared fluorescent [2] and soluble sulfonated cyanine dye [3] with a molecular weight of 828 Da[2], able to be dissolved in DMSO [1] and ready for conjugation to proteins [4]. Cy7 NHS ester acts as a donor of Cy7 [5]. Cy7 has an emission maximum at 767nm, an absorption maximum at 743nm and its ε743=200,000 cm-1M-1 [4]. Compared with Cy5.5, Cy7 has fewer sulfonate groups and an extra methine group that contributes to hydrophobicity. Antibodies labeled with either Cy7 or Cy5.5 succinimidyl esters have similar quenching efficiencies [5].N-acylation can occur between a Cy7 NHS ester and a primary amino group. This type of reaction is also widely used to allow amide formation under milder conditions without base or coupling reagent [6]. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, using of organic co-solvent (5-20% of DMF or DMSO) to dissolve this molecular is necessary for efficient reaction. Cyanine dye should be dissolved in organic solvent first, and added to a solution of biomolecule (protein, peptide, amino-labeled DNA) in appropriate aqueous buffer.Incubated with Cy7 NHS, LS174T cells showed negligible signals in fluorescent microscopic images, it illustrated that possibility of nonspecific binding between free Cy7 and LS174T cells was negligible [1].In vivo, injection of Cy7-NHS for 15 minutes resulted in the fluorescent signal
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Cy7 NHS ester
作者：德尔塔 日期：2022-09-26
Labeling of amino-groups in biomolecules.Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye. This reagent allows prepare Cy7-labeled biomolecules, especially useful for the labeling of delicate proteins, and proteins prone to denaturation. Dye labeled molecules can be used for kinds of researches related experiments. Near infrared fluorescent imaging takes advantage of transparency of biological tissues at particular range of wavelengths. In live organisms, the method is non-destructive, and allows monitor distribution of various labeled molecules. Non-sulfonated Cy7 NHS ester soluble in organic phase is also available. For labeling proteins and peptides, no organic co-solvent is needed. In life science, the sulfonate groups make the Cy dyes soluble in water and also reduce fluorescence-quenching which can arise from dye–dye interactions.In mice, Cy7-labeled RIG precursor solution and Cy7-labeled PIC micelles solution, was analyzed with an IVIS spectrum system. Administration of the Cy7-labeled RIG resulted in strong fluorescence signal in the mouth as compared with the orally administered Cy7-labeled PIC micelles solution [1].Reference:[1] Saita, M. ; Kaneko, J.; Sato, T.; Takahashi, S.; Takahashi, S.W.; Kawamata, R.; Sakurai, T.; Lee, M.-C.; Hamada, N.; Kimoto, K.; Nagasaki, Y. Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption. Biomaterials, 2016, 76, 292–301.Sulfo-Cy7 NHS ester is a sulfonated, hydrophilic and highly water soluble dye
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Cy7 maleimide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Labeling of cysteine residues, as well as other thiolated moleculesCy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. Labeled proteins thus obtained are used in NIR bioimaging applications. In tissues or in live organism, NIR imaging systems can be used to visualize distribution of labeled proteins. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In splenocytes, for ease of detection, P22 particles were labeled internally with Cy7-maleimide. P22-Cy7 alone or P22-Cy7 decorated with DecSelf was incubated with splenocytes at 37℃ to encourage phagocytosis [1].Reference:[1]. Schwarz, B.; Madden, P.; Avera, J.; Gordon, B.; Larson, K.; Miettinen, H.; Uchida, M.; LaFrance, B.; Basu, G.; Rynda-Apple, A.; Douglas, T. Symmetry Controlled, Genetic Presentation of Bio-Active Proteins on the P22 Virus-Like Particle Using an External Decoration Protein. ACS Nano, 2015, 9(9), 9134–9147.Cy7 maleimide is a near-infrared, sulfhydryl reactive dye which has low aqueous solubility. This reagent can label the proteins contain free sulfhydryl groups. Labeled proteins thus obtained are used in NIR bioimaging applications. In tissues or in live organism, NIR imaging systems can be used to visualize distribution of labeled proteins. For biomole
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Cy7 DiC18
作者：德尔塔 日期：2022-09-26
Cy7 DiC18 是一种亲脂、近红外荧光氰化物染料，用于膜染色。Cy7 DiC18 is a lipophilic, near-infrared fluorescent cyanine dye used for staining membranes.Cy7 DiC18 is a lipophilic, near-infrared fluorescent cyanine dye used for staining membranes.Cas No. 100068-60-8 SDF 别名 N/A 化学名 N/A Canonical SMILES CCCCCCCCCCCCCCCCCC[N+]1=C(/C=C/C=C/C=C/C=C2N(CCCCCCCCCCCCCCCCCC)C3=C(C=CC=C3)C/2(C)C)C(C)(C)C4=C1C=CC=C4.[I-] 分子式 C63H101IN2 分子量 1013.39 溶解度 Soluble in DMSO 储存条件 4°C, protect from light General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy7 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy7 carboxylic acid is a near-infrared fluorescent dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cy7, together with carboxylic acid (CA) make up the model drugs. On the basis of this, the study was able to estimate the amount of Cy7 carboxylic acid on the particle through direct emission spectra measurements [1].Reference:[1] Zhao, Y. ; Fay, F.; Hak, S.; Manuel Perez-Aguilar, J.; Sanchez-Gaytan, B.L.; Goode, B.; Duivenvoorden, R.; de Lange Davies, C.; Bjrky, A.; Weinstein, H.; Fayad, Z.A.; Pérez-Medina, C.; Mulder, W.J.M. Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy. Nature Communications, 2016,7,11221.Cy7 carboxylic acid is a near-infrared fluorescent dye which has low aqueous solubility. As for coupling and labeling reactions, pre-activated Cy7 NHS ester or water-soluble sulfo-Cy7 NHS ester would be considered. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of
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Cy7 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesCy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecules is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. This product can be used for the incorporation of Cy7 azide into various biomolecules and post-synthetic modification of oligonucleotides is also available. PEG-b-PPLG-Cy7 was conjugated by Cy7 azid and the polymer of PEG-b-PPLG. In blank micelles, it was used to probe the association of unimers [1].Reference:[1] Morton, S. W.; Zhao, X.; Quadir, M.A.; Hammond, P.T. FRET-enabled biological characterization of polymeric micelles. Biomaterials,2014, 35(11), 3489-3496.Cy7 azide is a labeling reagent that ready for the use in Click Chemistry labeling. This labeling dye is a near-infrared dye which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecules is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. This product can be used for the incorporation of Cy7 azide into various biomolecules and post-synthetic modification of oligonucleotides is also a
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CY7
作者：德尔塔 日期：2022-09-26
Cy7 (Sulfo-Cyanine7) 是一种荧光标记试剂 (Ex=750 nm，Em=773 nm)。Cyanine 染料可用于标记蛋白质，抗体，肽，寡聚核苷酸等。Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides[1].[1]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm). Cyanine dyes are used to label proteins, antibodies, peptides, and oligonucleotides[1].[1]. Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.Cas No. 943298-08-6 SDF 别名 N/A 化学名 N/A Canonical SMILES CC(/C(N1CCCCCC(O)=O)=C\C=C\C=C\C=C\C2=[N+](CC)C(C=CC(S(=O)([O-])=O)=C3)=C3C2(C)C)(C)C4=C1C=CC(S(=O)(O)=O)=C4 分子式 C35H42N2O8S2 分子量 682.85 溶解度 DMSO: ≥ 33 mg/mL (48.33 mM) 储存条件 Store at -20°C
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Cy5.5-SE
作者：德尔塔 日期：2022-09-26
Cy5.5-SE 是一种花青染料，可标记多肽、蛋白和寡核苷酸中的氨基。Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cy5.5-SE is a cyanine dye, labeling amino-groups in peptides, proteins, and oligonucleotides.Cas No. 442912-55-2 SDF 别名 N/A 化学名 N/A Canonical SMILES O=S(C1=CC(S(=O)([O-])=O)=C2C(C3=C([N+](CC)=C(/C=C/C=C/C=C4N(CCCCCC(ON5C(CCC5=O)=O)=O)C6=C(C7=CC(S(=O)(O)=O)=CC(S(=O)(O)=O)=C7C=C6)C/4(C)C)C3(C)C)C=C2)=C1)(O)=O 分子式 C45H47N3O16S4 分子量 1014.13 溶解度 Soluble in DMSO 储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
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Cy5.5 NHS ester (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Cy5.5-NHS ester is a near-infrared amine reactive dye for labeling amino groups of peptides, proteins and oligonucleotides.Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) }); Quality Control & SDS View current batch: 54321 Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet Purity: >98.00% COA (Certificate Of Analysis) Datasheet jQuery(document).ready(function(){ jQuery('#selectqc').change(function(){ var val = jQuery(this).val(); show_or_hidden(val,5); }) });Cell experiment [1]:Cell lines U87MGPreparation Method U87MG cells (1 ×
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Cy5.5 hydrazide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
carbonyl-reactive dyeCy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers. Glycoproteins also can be labeled after periodate oxidation to form aldehyde groups. Therefore, this dye is especially applicable for the labeling of antibody. Moreover, Cy5.5 is a near infrared fluorophore with prominent ability of tissue penetration, so it is suitable for the applications which require low fluorescence background, and for the in vivo NIR imaging. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.Cy5.5 hydrazide is a reactive dye for the labeling of biomolecules containing carbonyl groups, such as ketone and aldehydes. This dye pocesses a hydrazide group that can be used to label glycans at their reducing end or other reducing sugars, forming a hydrazone linkage. Hydrazide-containing Cyanine Dyes can react with glycoproteins and other glycoconjugates specifically via their carbohydrate groups without interfering binding site or active centers.
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Cy5.5 carboxylic acid (non-sulfonated)
作者：德尔塔 日期：2022-09-26
Non-reactive fluorophore, for control experiments, and for calibrationCy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α-CD hydrogel in vivo [1].Reference:[1] Wang, X. ; Wang, C.; Zhang, Q.; Cheng, Y. Near Infrared Light-responsive and Injectable Supramolecular Hydrogels for On-demand Drug Delivery. Chemical Communications, 2016, 52, 978–981.Cy5.5 carboxylic acid is an un-activated labeling regent which has low aqueous solubility. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cyanine 5.5 carboxylic acid instead of the drug was injected into the tumors in order to visually observe the dye release by using the in vivo imaging system (IVIS). Research show that NIR irradiation could efficiently triggered drug release from the DEPt-PEG/α
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Cy5.5 azide (non-sulfonated)
作者：德尔塔 日期：2022-09-26
used for Click chemistry to label alkyne-modified oligonucleotidesThis Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. In human glioblastoma U87MG cells, to assess the capability of the Cu(I)/M-dots for cell labeling Cy5.5-azide was in combination with Cu(I)/M-dots for imaging of the integrin αⅤβ3 receptor [1].Reference:[1] Sun, Y. ; Hong, S.; Ma, X.; Cheng, K.; Wang, J.; Zhang, Z.; Yang, M.; Jiang, Y.; Hong, X.; Cheng, Z. Recyclable Cu(I)/Melanin Dots for Cycloadditions, Bioconjugation and Cell Labeling. Chemical Science.This Cy5.5 is a labeling reagent that ready for the use in Click Chemistry reaction which available as 10 mM solution in DMSO. As Cy5.5 azide is a far-red emitting dye, it can replace Alexa Fluor 680, and DyLight 680. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, the labeling reagent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is nec
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