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3-Hydroxy agomelatine-d3，3-羟基阿戈美拉汀杂质7-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：3-Hydroxy agomelatine-d3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].IC50 & Target[1]：5-HT2C Receptor3.2 μM (IC50)5-HT2C Receptor1.8 μM (Ki)分子量：262.32Formula：C15H14D3NO3CAS 号：1079774-23-4非标记 CAS：166526-99-4性状：固体颜色：Off-white to light yellow中文名称：3-羟基阿戈美拉汀杂质7-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Zearalenone-13C18，玉米烯酮-13C18; Mycotoxin F2-13C18; Toxin F2-13C18「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Zearalenone-13C18 (Mycotoxin F2-13C18; Toxin F2-13C18) is the 13C labeled Zearalenone (HY-103447)[1]. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts[2][3].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：336.23Formula：13C18H22O5CAS 号：911392-43-3非标记 CAS：17924-92-4性状：液体颜色：Colorless to light yellow中文名称：玉米烯酮-13C18； 玉米赤霉烯酮-13C18；F-2 毒素-13C18运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Solution, -20°C, 2 years
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C16 Ceramide-d7 (d16:1,C16:0「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：C16 Ceramide-d7 (d16:1,C16:0) is the deuterium labeled C16 Ceramide (d16:1,C16:0)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：544.94Formula：C34H60D7NO3CAS 号：1840942-13-3非标记 CAS：123065-37-2性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Cefaclor-d5，头孢克洛 d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Cefaclor-d5 is the deuterium labeled Cefaclor. Cefaclor is an effective antibiotic agent, and specifically binds to penicillin-binding protein 3 (PBP 3)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cefaclor-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：372.84Formula：C15H9D5ClN3O4SCAS 号：1426173-90-1非标记 CAS：53994-73-3性状：固体颜色：White to off-white中文名称：头孢克洛 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥97.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Chambers HF, et al. Characterization of penicilli
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Deupirfenidone-d3，吡非尼酮-d3; LYT-100; AMR69-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Deupirfenidone-d3-d3 is the deuterium labeled Pirfenidone (HY-B0673)[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.体内研究(In Vivo)Administration of Pirfenidone (300 mg/kg/day) for 4 wk. Pirfenidone significantly attenuates the score when administered in Bleomycin (BLM)-treated mice (P
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Cyclophosphamide-d4，环磷酰胺 d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cyclophosphamide-d4 相关抗体:FANCA Antibody (YA2112)FANCD2 Antibody (YA3102)FANCB Antibody (YA2804)分子量：265.11Formula：C7H11D4Cl2N2O2PCAS 号：173547-45-0非标记 CAS：50-18-0性状：固体颜色：White to off-white中文名称：环磷酰胺 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥98.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279. [Content Brief][3]. al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6. [Content Brief][4]. Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosph
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Tolcapone-d4，Ro 40-7592-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Tolcapone-d4 is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Tolcapone-d4 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：277.27Formula：C14H7D4NO5CAS 号：1246816-93-2非标记 CAS：134308-13-7性状：固体颜色：Light yellow to yellow中文名称：托卡朋 d4运输条件：Room tempe
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Donepezil-d7 hydrochloride，E2020-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Donepezil-d7 hydrochloride 相关抗体:CHRNA9 AntibodyChAT Antibody分子量：423.00Formula：C24H23D7ClNO3CAS 号：1261394-20-0非标记 CAS：120011-70-3性状：固体颜色：Light yellow to yellow中文名称：多奈哌齐 d7 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.;Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropha
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Reboxetine-d5 mesylate，瑞波西汀-d5甲磺酸盐「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Reboxetine-d5 (mesylate) is the deuterium labeled Reboxetine-d5 (mesyla[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：414.53Formula：C20H22D5NO6SCAS 号：1285918-53-7非标记 CAS：71620-89-8性状：固体颜色：White to off-white中文名称：瑞波西汀-d5甲磺酸盐运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： ≥95.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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Amiodarone-d4 hydrochloride，盐酸胺碘酮-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Amiodarone-d4 (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Amiodarone-d4 hydrochloride 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：685.80Formula：C25H26D4ClI2NO3CAS 号：1216715-80-8非标记 CAS：19774-82-4性状：固体颜色：White to off-white中文名称：盐酸胺碘酮-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Topotecan-d6，拓扑替康-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Topotecan-d6 相关抗体:TOP2A AntibodyDXd Antibody (YA897)SN38 Antibody (YA923)Topoisomerase I Antibody (YA2237)分子量：427.48Formula：C23H17D6N3O5CAS 号：1044904-10-0非标记 CAS：123948-87-8性状：固体颜色：Light yellow to yellow中文名称：托泊替康-d6；拓扑替康-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料Data Sheet (529 KB)SDS (419 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells. [Content Brief][3]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an a
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Prochlorperazine Sulfoxide-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Prochlorperazine Sulfoxide-d3 is a deuterium labeled Prochlorperazine Sulfoxide. Prochlorperazine Sulfoxide is the major metabolite of the antiemetic Prochlorperazine[1][2].分子量：392.96Formula：C20H21D3ClN3OSCAS 号：1189943-37-0非标记 CAS：10078-27-0性状：固体颜色：White to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Bisoprolol-d5，比索洛尔-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Bisoprolol-d5 is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Bisoprolol-d5 相关抗体:ADRB2 AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量：330.47Formula：C18H26D5NO4CAS 号：1189881-87-5非标记 CAS：104344-23-2中文名称：比索洛尔-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Jillian G Baker, et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22. [Content Brief][3]. Maria Hoeltzenbein, et al. Pregnancy outcome after first trimes
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Cyclazodone-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Cyclazodone-d5 is the deuterium labeled Cyclazodone[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：221.27Formula：C12H7D5N2O2CAS 号：1246817-86-6非标记 CAS：14461-91-7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (521 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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Dehydro Aripiprazole-d8 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Dehydro Aripiprazole-d8 (hydrochloride) is the deuterium labeled Dehydro Aripiprazole hydrochloride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：490.88Formula：C23H18D8Cl3N3O2CAS 号：1215383-78-0非标记 CAS：1008531-60-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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