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「同位素标记抑制剂」CAS:1020718-66-4|Minoxidil-d10
作者：德尔塔生物 日期：2025-05-30
生物活性：Minoxidil-d10 (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Minoxidil-d10 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：219.31Formula：C9H5D10N5OCAS 号：1020718-66-4非标记 CAS：38304-91-5性状：固体颜色：White to off-white中文名称：米诺地尔-d10运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:166447-71-8|(E,E)-Farnesol-d6
作者：德尔塔生物 日期：2025-05-30
生物活性：(E,E)-Farnesol-d6 is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(E,E)-Farnesol-d6 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：228.40Formula：C15H20D6OCAS 号：166447-71-8非标记 CAS：106-28-5性状：液体颜色：Light yellow to yellow中文名称：(E,E)-法呢醇-d6； (E,E)-金合欢醇-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产
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「同位素标记抑制剂」CAS:1020719-62-3|Pirfenidone-d5
作者：德尔塔生物 日期：2025-05-30
生物活性：Pirfenidone-d5 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].IC50 & Target：TGF-β2[1][2]CCL2 and CCL12[3]分子量：190.25Formula：C12H6D5NOCAS 号：1020719-62-3非标记 CAS：53179-13-8性状：固体颜色：White to light yellow中文名称：吡非尼酮 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2699608-18-7|Acalabrutinib-d4
作者：德尔塔生物 日期：2025-05-30
生物活性：Acalabrutinib-d4 is a deuterium labeled Acalabrutinib. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor[1]. Acalabrutinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.分子量：469.53Formula：C26H19D4N7O2CAS 号：2699608-18-7非标记 CAS：1420477-60-6性状：固体颜色：Light yellow to light brown运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1189805-51-3|(±)-Levomepromazine-d6
作者：德尔塔生物 日期：2025-05-30
生物活性：(±)-Levomepromazine-d6 is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.分子量：334.51Formula：C19H18D6N2OSCAS 号：1189805-51-3非标记 CAS：851-68-3性状：固体颜色：White to yellow中文名称：(±)-左美丙嗪-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:64315-36-2|Acetaminophen-d4
作者：德尔塔生物 日期：2025-05-30
生物活性：Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Acetaminophen-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)p300 AntibodyGAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyHistone H3 (acetyl K27) AntibodyMETTL3 AntibodyAcetyl-Histone H3 (Lys27) AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyATRX AntibodyCalnexin Antibody (YA573)COX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyHistone H2A(acetyl K9) AntibodyHistone H3 (acetyl K14) AntibodyHistone H3 (acetyl K18) AntibodyHistone H3 (acetyl K56) AntibodyHistone H4 (acetyl K16) AntibodyHistone H4 (acetyl K8) AntibodyHistone H4 (acetyl K5) AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)分子量：155.19Formula：C8H5D4NO2CAS 号：64315-36-2非标记 CAS：103-90-2性状：固体颜色：White to off-white中文名称：对乙酰氨基酚 d4运输条件：Room temperature in
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「同位素标记抑制剂」CAS:147664-83-3|Citric acid-d4
作者：德尔塔生物 日期：2025-05-30
生物活性：Citric acid-d4 is the deuterium labeled Citric acid. Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Citric acid-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyAIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 Antibody分子量：196.15Formula：C6H4D4O7CAS 号：147664-83-3非标记 CAS：77-92-9性状：固体颜色：White to off-white中文名称：柠檬酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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「同位素标记抑制剂」CAS:1173022-56-4|4-Hydroxymephenytoin-d3
作者：德尔塔生物 日期：2025-05-30
生物活性：4-Hydroxymephenytoin-d3 is the deuterium labeled 4-Hydroxymephenytoin. 4-Hydroxymephenytoin is a metabolism of an antiepileptic agent mephenytoin, which is used as a CYP2C19 substrate[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.4-Hydroxymephenytoin-d3 相关抗体:FMO3 Antibody (YA1992)分子量：237.27Formula：C12H11D3N2O3CAS 号：1173022-56-4非标记 CAS：61837-65-8性状：固体颜色：White to light yellow中文名称：羟基香豆素-d3；4羟基美芬妥英-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:75502-10-2|Glycolic acid-d2
作者：德尔塔生物 日期：2025-05-30
生物活性：Glycolic acid-d2 is the deuterium labeled Glycolic acid. Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Glycolic acid-d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMiTF AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)ZAP70 Antibody (YP4051)Asparagine Synthetase AntibodyCalnexin AntibodyCD3 epsilon AntibodyCD3D AntibodyKi67 Antibody (YA001)分子量：78.06Formula：C2H2D2O3CAS 号：75502-10-2性状：固体颜色：White to off-white中文名称：乙醇酸 d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1476074-39-1|VX-984
作者：德尔塔生物 日期：2025-05-30
生物活性：VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium[1][2][3].体外研究(In Vitro)：VX-984 (0-500 nM，30 分钟) 抑制 U251 和 NSC11 细胞中辐射诱导的 DNA-PKcs 磷酸化[1]。VX-984 (0-500 nM) 以浓度依赖性方式增强 U251 和 NSC11 细胞的放射敏感性[1]。VX-984 抑制辐射诱导的 DNA 双链断裂 (DSB) 的修复[1]。VX-984 (0-1 μM) 增加 DSB 修复的替代途径，包括 HR（同源重组）和诱变 NHEJ (mNHEJ)[2]。氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。 氘代因其可能影响药物的药代动力学和代谢特征而受到关注[4]。氘代化合物的潜在优势：(1) 延长体内半衰期。 氘代化合物可能能够延长化合物的药代动力学特征，即延长体内半衰期。 这可以提高化合物的安全性、功效和耐受性，并增加给药的便利性。 (2)提高口服生物利用度。 氘化化合物可以降低肠壁和肝脏中不需要的代谢（首过代谢）的程度，使更大比例的未代谢药物到达其作用靶点。 高生物利用度决定了它在低剂量下的活性和更好的耐受性。 (3)改善代谢特性。 氘代化合物可以减少有毒或反应性代谢物的形成并改善药物代谢。 （四）提高用药安全性。 氘代化合物可以减少或消除药物化合物的不良副作用并且是安全的。 (5) 保持治疗特性。 在先前的研究中，预计氘代化合物将保留与氢类似物相似的生化效力和选择性。 德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.VX-984 相关抗体:Ku70 Antibody (YA715)Ku80 AntibodyKu70 Antibody (YA319)Ku80 Antibody (YA714)Phospho-DNA PKcs (
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「同位素标记抑制剂」CAS:80143-57-3|L-Glutamine-15N
作者：德尔塔生物 日期：2025-05-30
生物活性：L-Glutamine-15N is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells[1][2].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.L-Glutamine-15N 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyFMRP AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMetabotropic glutamate receptor 5 AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Glutamate receptor 1 AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyAMID/FSP1 Antibody分子量：147.14Formula：C5H10N15NO3CAS 号：80143-57-3非标记 CAS：56-85-9性状：固体颜色：White to off-white中文名称：L-谷氨酰胺 15N运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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「同位素标记抑制剂」CAS:718612-49-8|SN-38-d3
作者：德尔塔生物 日期：2025-05-30
生物活性：SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.SN-38-d3 相关抗体:TOP2A AntibodyDXd Antibody (YA897)MMAE Antibody (YA899)MMAF Antibody (YA900)SN38 Antibody (YA923)Topoisomerase I Antibody (YA2237)分子量：395.42Formula：C22H17D3N2O5CAS 号：718612-49-8非标记 CAS：86639-52-3性状：固体颜色：Off-white to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:161096-83-9|2-Ketoglutaric acid-13C5
作者：德尔塔生物 日期：2025-05-30
生物活性：2-Ketoglutaric acid-13C5 is the 13C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2-Ketoglutaric acid-13C5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMiTF AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)ZAP70 Antibody (YP4051)Asparagine Synthetase AntibodyCalnexin AntibodyCD3 epsilon AntibodyCD3D AntibodyKi67 Antibody (YA001)分子量：151.06Formula：13C5H6O5CAS 号：161096-83-9性状：固体颜色：White to off-white中文名称：α-酮戊二酸-13C5运输条件：Room temperature in continental US; may vary elsewhere.储
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「同位素标记抑制剂」CAS:14314-42-2|Water-18O
作者：德尔塔生物 日期：2025-05-30
生物活性：Water-18O is the 18O-labeled Water[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：20.02Formula：H218OCAS 号：14314-42-2非标记 CAS：7732-18-5性状：液体（密度：1.11 g/cm3）颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.99%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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「同位素标记抑制剂」CAS:121662-14-4|Ibuprofen-d3
作者：德尔塔生物 日期：2025-05-30
生物活性：Ibuprofen-d3 is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ibuprofen-d3 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：209.30Formula：C13H15D3O2CAS 号：121662-14-4非标记 CAS：15687-27-1性状：固体颜色：White to off-white中文名称：布洛芬 d3 杂质82运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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