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Telaprevir-d4，VX-950-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Telaprevir-d4 is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Telaprevir-d4 相关抗体:Cyclophilin A AntibodyCyclophilin B Antibody (YA787)分子量：683.87Formula：C36H49D4N7O6非标记 CAS：402957-28-2中文名称：特拉普韦 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (530 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Lin K, et al. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob Agents Chemother. 2006 May;50(5):1813-22. [Content Brief][3]. Perni RB, et al. Preclinical profile
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Atorvastatin lactone-d5，阿托伐他汀EP杂质H-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Atorvastatin lactone-d5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].分子量：545.66Formula：C33H28D5FN2O4非标记 CAS：125995-03-1中文名称：阿托伐他汀EP杂质H-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9. [Content Brief]
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Dabigatran-13C,d3，达比加群-13C,d3; BIBR 953-13C,d3; BIBR 953ZW-13C,d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Dabigatran-13C,d3 is the 13C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[58].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Dabigatran-13C,d3 相关抗体:PAR2 Antibody (YA2455)Protein C Antibody (YA2461)Thrombomodulin Antibody (YA891)Thrombomodulin Antibody (YA892)F2 AntibodyPAR6 Antibody (YA1536)Prothrombin Antibody (YA1753)PAR4 Antibody (YA2603)Protein S Antibody (YA2919)分子量：475.52Formula：C2413CH22D3N7O3非标记 CAS：211914-51-1中文名称：达比加群-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief][2]. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66. [Content Brief][3]. Wienen W, Stassen
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Harmane-d2，哈尔满碱 d2「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Harmane-d2 相关抗体:ADRB2 AntibodyMonoamine Oxidase A Antibody (YA2036)Monoamine Oxidase B Antibody (YA2039)Salbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量：184.23Formula：C12H8D2N2非标记 CAS：486-84-0中文名称：哈尔满碱 d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (539 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Louis ED, et, al. Blood harmane concentrations and dietary protein consu
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Quinolinic acid-13C4,15N，喹啉酸-13C4,15N「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist and has the potential of mediating NMDA neuronal damage and dysfunction[1].分子量：172.08Formula：C313C4H515NO4非标记 CAS：89-00-9中文名称：喹啉酸-13C4,15N运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73. [Content Brief]
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Dexmedetomidine-13C,d3 hydrochloride，盐酸右美托咪定-13C,d3; (+-Medetomidine-13C,d3 hydrochloride; (S-Medetomidine-13C,d3 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Dexmedetomidine-13C,d3 (hydrochloride) is the 13C- and deuterium labeled Dexmedetomidine (hydrochloride). Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a Ki of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[78].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Dexmedetomidine-13C,d3 hydrochloride 相关抗体:ADRB2 AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量：240.75Formula：C1213CH14D3ClN2非标记 CAS：145108-58-3性状：固体颜色：White to off-white中文名称：盐酸右美托咪定-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： 99.93%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief][2]. Virtanen R, et, al. Characterization of the
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Apalutamide-13C,d3，ARN-509-13C,d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Apalutamide-13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[38].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Apalutamide-13C,d3 相关抗体:Androgen receptor AntibodyPOMC Antibody (YA1619)分子量：481.45Formula：C2013CH12D3F4N5O2S非标记 CAS：956104-40-8性状：固体颜色：White to off-white中文名称：阿帕鲁胺-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Efinaconazole-d4，KP-103-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Efinaconazole-d4 is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Efinaconazole-d4 相关抗体:SDHA Antibody分子量：352.41Formula：C18H18D4F2N4O非标记 CAS：164650-44-6性状：固体颜色：White to off-white中文名称：艾氟康唑 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Delafloxacin-d5，德拉沙星-d5; RX-3341-d5; WQ-3034-d5; ABT492-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Delafloxacin-d5 is deuterium labeled Delafloxacin. Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Delafloxacin-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：445.79Formula：C18H7D5ClF3N4O4非标记 CAS：189279-58-1性状：固体颜色：Light yellow to yellow中文名称：德拉沙星-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.76%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharma
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Riociguat-13C,d6，利奥西呱-13C,d6; BAY 632521-13C,d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Riociguat-13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.IC50 & Target：sGC[2]体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].Riocigua stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism[1]. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.体内研究(In Vivo)Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature in chronic treatment of hypoxic mice and MCT-injected rats[3].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT00454558BayerHypertension, PulmonaryJanuary 2007Phase 2NCT04062565University of ArizonaPulmonary Arterial HypertensionMarch 25, 2019Phase 3NCT02117791BayerHypertension, PulmonaryJuly 16, 2014 NCT00680654BayerHyper
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Sitagliptin-d4 hydrochloride，MK-0431-d4 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Sitagliptin-d4 (hydrochloride) is the deuterium labeled Sitagliptin[1]. Sitagliptin (MK-0431) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Sitagliptin-d4 hydrochloride 相关抗体:DPP4/CD26 Antibody (YA1274)分子量：447.80Formula：C16H12D4ClF6N5O非标记 CAS：486460-32-6性状：固体颜色：White to off-white中文名称：西格列汀-d4；西他列汀-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： 99.22%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008 Apr;325(1):175-82. [Content Brief][3]. Kim, S.J., et al., Dipeptid
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Oclacitinib-13C-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Oclacitinib-13C-d3 is the deuterium and 13C labeled Oclacitinib[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：341.45Formula：C1413CH20D3N5O2S非标记 CAS：1208319-26-9性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Dacomitinib-d10 dihydrochloride，PF-00299804-d10 dihydrochloride; PF-299804-d10 dihydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Dacomitinib-d10 (dihydrochloride) is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：552.92Formula：C24H17D10Cl3FN5O2非标记 CAS：1110813-31-4性状：固体颜色：White to off-white中文名称：达克替尼 d10 (双盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度： ≥95.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Engelman JA, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to ZD1839. Cancer Res. 2007 Dec 15;67(24):11924-32. [Content Brief][3]. Kalous O, et al. Dacomitinib (PF-00299804), an irreversible Pan-HER inhibitor, inhibits proliferation of HER2-amplified breast cancer cell lines resistant to Anti-Hu
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Doxapram-d5 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：Doxapram-d5 (hydrochloride) is deuterium labeled Doxapram (hydrochloride).体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：420.00Formula：C24H26D5ClN2O2非标记 CAS：113-07-5性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： ≥99.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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DL-Methyldopa-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-05-29
生物活性：DL-Methyldopa-d3 is deuterium labeled DL-Methyldopa.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：214.23Formula：C10H10D3NO4非标记 CAS：55-40-3性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 98.17%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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