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Demethoxycurcumin-d7，Curcumin II-d7; Desmethoxycurcumin-d7; Monodemethoxycurcumin-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Demethoxycurcumin-d7 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin(Curcumin II), a major active curcuminoid, possess anti-inflammatory properties; also exert cytotoxic effects in human cancer cells via induction of apoptosis.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Demethoxycurcumin-d7 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：345.40Formula：C20H11D7O5CAS 号：2470243-19-5非标记 CAS：22608-11-3中文名称：去甲氧基姜黄素 d7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使
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(±-Epicatechin-13C3，表儿茶素-13C3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：(±)-Epicatechin-13C3 is the 13C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(±)-Epicatechin-13C3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)COX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyAMID/FSP1 Antibody分子量：293.25Formula：C1213C3H14O6CAS 号：1217780-28-3非标记 CAS：490-46-0中文名称：表儿茶素-13C3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate
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1-Acetylnaphthalene-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：1-Acetylnaphthalene-d3 is the deuterium labeled 1-Acetylnaphthalene[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：173.23Formula：C12H7D3OCAS 号：95046-87-0非标记 CAS：941-98-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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Regorafénib N-oxyde (M2-13C,d3，瑞戈非尼氮氧化物(M2代谢物-13C,d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Regorafénib N-oxyde (M2)-13C,d3 is the 13C- and deuterium labeled Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[90].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Regorafénib N-oxyde (M2)-13C,d3 相关抗体:FMO3 Antibody (YA1992)分子量：502.83Formula：C2013CH12D3ClF4N4O4CAS 号：2140317-01-5非标记 CAS：835621-11-9中文名称：瑞戈非尼氮氧化物(M2代谢物)-13C,d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief][2]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48. [Content Brief]
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Regorafénib N-oxyde-d3(M2，瑞格非尼 N-氧化物(M2代谢物杂质13-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Regorafénib N-oxyde-d3(M2) 相关抗体:Phospho-PDGFR beta (Y740) AntibodyPDGFR alpha AntibodyPDGF B Antibody (YA1556)PDGFR beta Antibody (YA1925)FMO3 Antibody (YA1992)Phospho-PDGFR beta (Tyr740) Antibody (YA3062)分子量：501.83Formula：C21H12D3ClF4N4O4CAS 号：1333489-03-4非标记 CAS：835621-11-9中文名称：瑞格非尼 N-氧化物(M2代谢物)杂质13-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal
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(Rac-Ambrisentan-d5，(Rac-安倍生坦-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：(Rac)-Ambrisentan-d5 is deuterium labeled (Rac)-Ambrisentan.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：383.45Formula：C22H17D5N2O4CAS 号：1392210-85-3非标记 CAS：713516-99-5中文名称：(Rac)-安倍生坦-d5； (Rac)-安立生坦-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyPhospho-PKC alpha (T638) AntibodyPhospho-PKC zeta (T560) AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)PKC alpha AntibodyPKC beta 1 AntibodyPKC beta 2 AntibodyPKC delta AntibodyPKC epsilon AntibodyPKC gamma AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)分子量：653.06Formula：C41H64D8O5CAS 号：2692624-31-8非标记 CAS：65914-84-3运输条件：Room temperature in continental US; may var
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Desmethylcyclobenzaprine-d3 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Desmethylcyclobenzaprine-d3 (hydrochloride) is deuterium labeled Desmethylcyclobenzaprine (hydrochloride).体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：300.84Formula：C19H17D3ClNCAS 号：1784139-98-5非标记 CAS：438-59-5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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4-Methylhippuric acid-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：4-Methylhippuric acid-d7 is the deuterium labeled 4-Methylhippuric acid[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：200.24Formula：C10H4D7NO3CAS 号：1216588-60-1非标记 CAS：27115-50-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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Dimethyldioctadecylammonium-d74 bromide，Dimethyldistearylammonium-d74 Bromide「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Dimethyldioctadecylammonium-d74 (bromide) is the deuterium labeled Dimethyldioctadecylammonium bromide[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：705.41Formula：C38H6D74BrNCAS 号：1111808-79-7非标记 CAS：3700-67-2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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Cimbuterol-d9，CIMBUTEROL标准品-d9「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Cimbuterol-d9 is the deuterium labeled Cimbuterol. Cimbuterol is aβ-adrenergic agonist[1].IC50 & Target：β adrenergic receptor分子量：242.36Formula：C13H10D9N3OCAS 号：1246819-04-4非标记 CAS：54239-39-3中文名称：CIMBUTEROL标准品-d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (523 KB)产品使用指南 (1538 KB)参考文献[1]. Mastrianni KR, et al. Analysis of 10 β-agonists in pork meat using automated dispersive pipette extraction and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1084:64-68. [Content Brief]
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Brombuterol-d9 hydrochloride，Bromobuterol d9 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Brombuterol-d9 (hydrochloride) is a deuterium labeled Brombuterol hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist[1].IC50 & Target：β adrenergic receptor分子量：411.61Formula：C12H10D9Br2ClN2OCAS 号：1353867-94-3非标记 CAS：21912-49-2中文名称：溴布特罗 d9 盐酸盐运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. E Sangiorgi, et al. Application of a Sequential Analytical Procedure for the Detection of the Beta-Agonist Brombuterol in Bovine Urine Samples. J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):468-78. [Content Brief]
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7-Hydroxymethotrexate-d3，7-羟基甲氨蝶呤-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.7-Hydroxymethotrexate-d3 相关抗体:FMO3 Antibody (YA1992)分子量：473.46Formula：C20H19D3N8O6CAS 号：432545-62-5非标记 CAS：5939-37-7中文名称：7-羟基甲氨蝶呤-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60. [Content Brief][2]. Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal.
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82，1-棕榈酰基-2-油酰基卵磷脂-d8; POPC-d82「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：842.58Formula：C42D82NO8PCAS 号：2260669-94-9非标记 CAS：26853-31-6中文名称：1-棕榈酰基-2-油酰基卵磷脂-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Moreno MJ, et al. Translocation of phospholipids and dithionite permeability in liquid-ordered and liquid-disordered membranes. Biophys J. 2006 Aug 1;91(3):873-81. [Content Brief][2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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Alectinib-d6，艾乐替尼-d6; CH5424802-d6; RO5424802-d6; AF802-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Alectinib-d6 相关抗体:ALKBH2 Antibody (YA2047)ALKBH4 Antibody (YA2050)ALK-1 Antibody (YA2457)ALKBH1 Antibody分子量：488.65Formula：C30H28D6N4O2CAS 号：1616374-19-6非标记 CAS：1256580-46-7性状：固体颜色：White to off-white中文名称：艾乐替尼-d6；阿雷替尼-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 98.05%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011, 19(5), 679-690. [Content Brief][3]. Gadgeel S, et al. Alectinib versus cri
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