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Etoricoxib-d4，依托考昔 D4; MK-0663-d4; L-791456-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Etoricoxib-d4 is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.分子量：362.87Formula：C18H11D4ClN2O2SCAS 号：1131345-14-6非标记 CAS：202409-33-4性状：固体颜色：Light yellow to yellow中文名称：依托考昔 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：2 years-20°C：1 year
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Baricitinib-d3，LY3009104-d3; INCB028050-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Baricitinib-d3 is the deuterium labeled Baricitinib. Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Baricitinib-d3 相关抗体:Phospho-JAK2 (Tyr1007/1008) AntibodyJAK1 Antibody (YA722)JAK1 AntibodyJAK2 Antibody (YA721)Phospho-JAK2 (Tyr1007+Tyr1008) AntibodyJAK2 Antibody (YA330)Phospho-JNK (Thr183) AntibodyJAK3 Antibody (YA2466)分子量：374.44Formula：C16H14D3N7O2SCAS 号：1564242-30-3非标记 CAS：1187594-09-7性状：固体颜色：White to off-white中文名称：巴瑞克替尼 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Fridman JS, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010 May 1;184(9):5298-307. [Content Brief][3]. Jabbari A, et al. Reversal of Alopecia Areata Following Treatmen
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PSI-6206-13C,d3，RO-2433-13C,d3; GS-331007-13C,d3; Sofosbuvir metabolite GS-331007-13C,d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：PSI-6206-13C,d3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.分子量：264.23Formula：C913CH10D3FN2O5CAS 号：1256490-42-2非标记 CAS：863329-66-2性状：固体颜色：White to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Repaglinide-d5，瑞格列奈 D5; AG-EE 623ZW d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Repaglinide-d5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus[1].体外研究(In Vitro)：Repaglinide reduces postprandial glucose levels by enhancing the early phase of insulin secretion and increasing the total amount of insulin secreted[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Repaglinide-d5 相关抗体:ATP1A1 AntibodyLGI1 Antibody (YA2885)Cardiac Troponin C Antibody (YA2125)Cardiac Troponin T Antibody (YA2719)SAP97 Antibody (YA2731)Kir2.1 Antibody (YA2871)分子量：457.62Formula：C27H31D5N2O4CAS 号：1217709-85-7非标记 CAS：135062-02-1性状：固体颜色：White to off-white中文名称：瑞格列奈 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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(±-Naproxen-d3，(Rac-Naproxen-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：(±)-Naproxen-d3 is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID)[1].分子量：233.28Formula：C14H11D3O3CAS 号：958293-79-3非标记 CAS：23981-80-8性状：固体颜色：Off-white to light yellow中文名称：萘普生 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Acetaminophen-d3，对乙酰氨基酚-d3; Paracetamol-d3; 4-Acetamidophenol-d3; 4'-Hydroxyacetanilide-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Acetaminophen-d3 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Acetaminophen-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)p300 AntibodyGAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyHistone H3 (acetyl K27) AntibodyMETTL3 AntibodyAcetyl-Histone H3 (Lys27) AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyATRX AntibodyCalnexin Antibody (YA573)COX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyHistone H2A(acetyl K9) AntibodyHistone H3 (acetyl K14) AntibodyHistone H3 (acetyl K18) AntibodyHistone H3 (acetyl K56) AntibodyHistone H4 (acetyl K16) AntibodyHistone H4 (acetyl K8) AntibodyHistone H4 (acetyl K5) AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)分子量：154.18Formula：C8H6D3NO2CAS 号：60902-28-5非标记 CAS：103-90-2性状：固体颜色：Light yellow to yellow中文名称：对乙酰氨基酚-d3；乙酰氨基酚-d3；扑热息痛
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4-Fluorobenzaldehyde-2,3,5,6-d4，4-Fluorobenzaldehyde--d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：4-Fluorobenzaldehyde-2,3,5,6-d4 is the deuterium labeled 4-Fluorobenzaldehyde-2,3,5,6-d4[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：128.14Formula：C7HD4FOCAS 号：93111-27-4非标记 CAS：459-57-4性状：液体颜色：Colorless to light yellow中文名称：对氟苯甲醛-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Amantadine-d15，金刚烷胺-d15; 1-Adamantanamine-d15; 1-Aminoadamantane-d15「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Amantadine-d15 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：166.34Formula：C10H2D15NCAS 号：33830-10-3非标记 CAS：768-94-5性状：固体颜色：White to off-white中文名称：金刚烷胺-d15运输条件：Room temperature in continental US; may vary
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4-Fluorobenzoic-2,3,5,6-d4 acid，4-FLUOROBENZOIC-d4 ACID「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：4-Fluorobenzoic-2,3,5,6-d4 acid is the deuterium labeled 4-Fluorobenzoic-2,3,5,6-d4 acid[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：144.14Formula：C7HD4FO2CAS 号：93111-25-2中文名称：4-氟苯甲酸 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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L-838417-d9「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：L-838417-d9 is the deuterium labeled L-838417. L-838417 is a subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].分子量：408.45Formula：C19H10D9F2N7OCAS 号：1213669-91-0性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Niflumic acid-13C6，氟尼酸-13C6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Niflumic acid-13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Niflumic acid-13C6 相关抗体:Anoctamin 1 AntibodyCLIC4 Antibody (YA2517)CLIC1 Antibody (YA2807)分子量：288.17Formula：C713C6H9F3N2O2CAS 号：1325559-33-8非标记 CAS：4394-00-7性状：固体颜色：White to light yellow中文名称：尼氟灭酸-13C6；尼氟酸-13C6；氟尼酸-13C6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.8%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Criddle, D.N., et al., Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol, 1997. 120(5): p. 813-8. [Content Brief][3]. Jabeen, T., et al., Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phosphol
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Uridine triphosphate-13C9,15N2 sodium，UTP-13C9,15N2 sodium; Uridine 5'-triphosphate-13C9,15N2 sodium「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Uridine triphosphate-13C9,15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.Formula：13C9H1515N2O15P3.xNaCAS 号：285978-18-9非标记 CAS：63-39-8性状：固体颜色：White to off-white中文名称：尿苷三磷酸 13C9,15N2 (钠盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料Data Sheet (499 KB)SDS (393 KB)产品使用指南 (1538 KB)
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Terbinafine-d3 hydrochloride，TDT 067-d3 hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Terbinafine-d3 (hydrochloride) is the deuterium labeled Terbinafine hydrochloride. Terbinafine hydrochloride (TDT 067 hydrochloride) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM[1][2]. Terbinafine hydrochloride also antibacterial activity against certain Gram-positive and Gram-negative bacteria[3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Terbinafine-d3 hydrochloride 相关抗体:SDHA AntibodyMRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：330.91Formula：C21H23D3ClNCAS 号：1310012-15-7非标记 CAS：78628-80-5性状：固体颜色：White to off-white中文名称：盐酸特比萘芬 d3 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, sealed s
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Ethyl acetoacetate-d5，Ethyl acetylacetate-d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Ethyl acetoacetate-d5 is the deuterium labeled Ethyl acetoacetate[1]. Ethyl acetoacetate (Ethyl acetylacetate) is an ester widely used as an intermediate in the synthesis of many varieties of compounds[2][3][4]. Ethyl acetoacetate is an inhibitor of bacterial biofilm[5].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ethyl acetoacetate-d5 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：135.17Formula：C6H5D5O3CAS 号：55514-60-8性状：液体颜色：Colorless to light yellow中文名称：乙酰乙酸乙酯-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Pure form-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Deutenzalutamide-d3，Enzalutamide-d3; MDV3100-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-09-17
生物活性：Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。氘代化合物的潜在优势：（1）延长体内半衰期。氘代化合物或能够延长化合物的药代动力学特征，即延长体内半衰期。由此可提高化合物安全性、有效性和耐受性，并增加给药的便捷性。（2）提高口服生物利用度。氘代化合物或能够减少肠壁和肝脏中不需要的代谢 (首过代谢) 程度，使得更大比例的未代谢药物到达作用的目标位置。生物利用度高决定其在低剂量下具有活性以及更好的耐受性。（3）改善代谢特征。氘代化合物或能够减少有毒或反应性代谢物的形成，改善药物代谢状况。（4）改进药品安全性。氘代化合物或能够减少或消除药物化合物的不良副作用，具有安全性。（5）保留治疗特性。氘代化合物有望保留和此前研究中氢类似物相似的生化效力和选择性。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Deutenzalutamide-d3 相关抗体:Androgen receptor AntibodyPOMC Antibody (YA1619)分子量：467.45Formula：C21H13D3F4N4O2SCAS 号：1443331-82-5非标记 CAS：915087-33-1性状：固体颜色：White to off-white中文名称：恩杂鲁胺 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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