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「同位素标记抑制剂」Tegoprazan-d6
作者：德尔塔生物 日期：2025-06-12
生物活性：Tegoprazan (CJ-12420; RQ-00000004), a potassium-competitive acid blocker, is a reversible, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro. Tegoprazan significantly improves colitis in mice and enhances the intestinal epithelial barrier function. Tegoprazan is promising for research of Inflammatory bowel, gastric acid-related, motilityimpaired diseases[1][2][3].体外研究(In Vitro)：Tegoprazan (1.0 mM and 3.0 mM, 4 h) 通过维持 Caco-2 细胞上皮粘膜的高连接完整性来减少 DSS 诱导的结肠炎[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Tegoprazan-d6 相关抗体:ATP7B Antibody (YA2029)ATP1B1 Antibody (YA2084)ATP6V1A Antibody (YA2211)ATPB Antibody (YA2214)ATP5F1A Antibody (YA2306)ATP1A2 Antibody (YA2934)PMCA1 Antibody (YA1676)ATP1B3 Antibody (YA2201)ATP5G Antibody (YA2205)ATP6V0D1 Antibody (YA2208)ATP1A3 Antibody (YA2462)ATP4B Antibody (YA2972)RT-PCR[1]Cell Line:Caco-2 cellsConcentration:1.0 mM and 3.0 mMIncubation Time:4 hResult:Protected the intestinal epithelial tight junction barrier and inhibits the increase in intestinal permeability.体内研究(In Vivo)Tegoprazan (30 mg/kg, 口服, 每天两次, 持续 5 天) 减轻了二硝基苯磺酸 (DNBS) 诱导的结肠长度和结肠损伤的严重程度，以及保护小鼠结肠免受 DNBS 诱导的结肠炎症[1]。Tegoprazan (3 mg/kg 和 10 mg/kg, 口服, 5 h) 以剂量依赖的方式抑制基础胃酸分泌[2]。Tegoprazan (0.1, 1 和 10 mg/kg, 口服) 具有剂量依赖性的抗溃疡作
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「同位素标记抑制剂」Bortezomib trimer-d15
作者：德尔塔生物 日期：2025-06-12
生物活性：Bortezomib trimer-d15 is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)（Bortezomib Impurity）.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：1113.76Formula：C57H54D15B3N12O9非标记 CAS：390800-88-1运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (532 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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「同位素标记抑制剂」Taurolithocholic acid-d4-1 sodium
作者：德尔塔生物 日期：2025-06-12
生物活性：Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Taurolithocholic acid-d4-1 sodium 相关抗体:Annexin VI AntibodyBNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalbindin AntibodyCalnexin Antibody (YA573)Calreticulin AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量：509.71Formula：C26H40D4NNaO5S非标记 CAS：6042-32-6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (523 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitutio
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「同位素标记抑制剂」(1S,2R)-Tranylcypromine-d5 hydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：(1S,2R)-Tranylcypromine-d5 (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.(1S,2R)-Tranylcypromine-d5 hydrochloride 相关抗体:Monoamine Oxidase A Antibody (YA2036)Monoamine Oxidase B Antibody (YA2039)分子量：174.68Formula：C9H7D5ClN非标记 CAS：1986-47-6中文名称：反式-2-苯基环丙胺盐酸盐-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Lee MG, et al. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Che
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「同位素标记抑制剂」Megestrol-d5
作者：德尔塔生物 日期：2025-06-12
生物活性：Megestrol-d5 is the deuterium labeled Megestrol. Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Megestrol-d5 相关抗体:FMO3 Antibody (YA1992)分子量：347.50Formula：C22H25D5O3非标记 CAS：3562-63-8中文名称：醋酸甲地孕酮EP杂质B-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (532 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1. [Content Brief]
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「同位素标记抑制剂」Methapyrilene-d6 hydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：Methapyrilene-d6 (hydrochloride) is the deuterium labeled Methapyrilene hydrochloride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：303.88Formula：C14H14D6ClN3S运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (522 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」Nilvadipine-d4
作者：德尔塔生物 日期：2025-06-12
生物活性：Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Nilvadipine-d4 相关抗体:Annexin VI AntibodyCalbindin AntibodyCalreticulin AntibodyCardiac Troponin I/TNNC1 AntibodySCGN Antibody (YA1167)RAMP1 Antibody (YA1818)Annexin V Antibody (YA1829)Striatin 4 Antibody (YA2088)Fibulin 5 Antibody (YA2448)RASGRP1 Antibody (YA2546)Fibulin 1 Antibody (YA2831)EFEMP1 Antibody (YA2883)CRCP Antibody (YA3350)Annexin VII Antibody (YA1138)Parvalbumin Antibody (YA1249)Annexin IV Antibody (YA1921)SERCA2 ATPase Antibody (YA1931)Stromal Interaction Molecule 1 Antibody (YA2092)SERCA1 ATPase Antibody (YA2157)TrpV5 Antibody (YA2284)NCX1 Antibody (YA2331)Scramblase 1 Antibody (YA2419)CAB39 Antibody (YA2761)CUG BP1 Antibody (YA2806)C10orf63 Antibody (YA2894)ITPK1 Antibody (YA3125)ORAI3 Antibody (YA3128)ORAI1 Antibody (YA3157)CREB Regulated Transcription Coactivator 2 Antibody (YA3279)分子量：389.40Formula：C19H15D4N3O6非标记 CAS：75530-68-6中文名称：尼伐地平-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in t
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「同位素标记抑制剂」Prochlorperazine-d3 mesylate
作者：德尔塔生物 日期：2025-06-12
生物活性：Prochlorperazine-d3 (mesylate) is the deuterium labeled Prochlorperazine mesylate[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：569.17Formula：C22H29D3ClN3O6S3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (521 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」Escitalopram-d4 oxalate
作者：德尔塔生物 日期：2025-06-12
生物活性：Escitalopram-d4 (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Escitalopram-d4 oxalate 相关抗体:Serotonin Transporter Antibody (YA1638)HTR7 Antibody (YA2796)HTR2C Antibody (YA3364)分子量：418.45Formula：C22H19D4FN2O5非标记 CAS：219861-08-2中文名称：草酸艾司西酞普兰-d4； 依他普仑草酸盐-d4； 草酸右旋西酞普兰-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Zhang, P., et al., Structure-activity relatio
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「同位素标记抑制剂」Apatinib 25-N-oxide-d8 dihydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：Apatinib 25-N-oxide-d8 (dihydrochloride) is the deuterium labeled Apatinib 25-N-oxide dihydrochloride[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：494.44Formula：C24H17D8Cl2N5O2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (526 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」Omecamtiv mecarbil-d8
作者：德尔塔生物 日期：2025-06-12
生物活性：Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Omecamtiv mecarbil-d8 相关抗体:Moesin AntibodyMyosin heavy chain AntibodyMyosin Light Chain 2 AntibodyMyosin light chain kinase AntibodyCalponin 1 AntibodyMYO7A Antibody (YA1665)MYL9 Antibody (YA2093)Tropomyosin alpha 1 Chain Antibody (YA2183)Phospho-Moesin (Thr558) Antibody (YA2614)MYL2 Antibody (YA2709)MYH9 Antibody (YA3113)MYH10 Antibody (YA3114)MYLK Antibody (YA3133)MYH6 Antibody (YA3200)MYH11 Antibody (YA1620)Troponin I Antibody (YA1832)Tropomodulin 2 Antibody (YA2771)MYH7B Antibody (YA2857)MYO19 Antibody (YA3282)MYO1B Antibody (YA3284)分子量：409.48Formula：C20H16D8FN5O3非标记 CAS：873697-71-3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Morgan BP, et al. Discovery of ome
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「同位素标记抑制剂」Propantheline-d3 iodide
作者：德尔塔生物 日期：2025-06-12
生物活性：Propantheline-d3 (iodide) is the deuterium labeled Propantheline iodide[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：498.41Formula：C23H27D3INO3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」(-)-Erinacin A-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：(-)-Erinacin A-d3 is the deuterium labeled (-)-Erinacin A[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：449.59Formula：C26H35D3O6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (522 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」5,6-Orthoquinone Primaquine-d6 hydrobromide
作者：德尔塔生物 日期：2025-06-12
生物活性：5,6-Orthoquinone Primaquine-d6 (hydrobromide) is the deuterium labeled 5,6-Orthoquinone Primaquine hydrobromide[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Formula：C14H12D6BrN3O2.xHBr非标记 CAS：214283-58-6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (520 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」2-Deoxy-2-fluoro-D-glucose-13C,d7
作者：德尔塔生物 日期：2025-06-12
生物活性：2-Deoxy-2-fluoro-D-glucose-13C,d7 is the deuterium labeled Methyl alpha-D-glucopyranoside[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：195.15Formula：13C6H4D7FO5非标记 CAS：29702-43-0运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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