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Dapsone-d8，4,4′-Diaminodiphenyl sulfone-d8; DDS-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].体外研究(In Vitro)：氨苯砜 (0.06 mM; 30 min) 抑制 N-Formyl-Met-Leu-Phe.html" class="link-product" target="_blank">N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) 和生理激动剂 C5a (100 nM) 触发的细胞内外超氧化物 (O2-) 和胰蛋白酶 E 的释放，而不是对 Phorbol 12-myristate 13-acetate.html" class="link-product" target="_blank">Phorbol 12-myristate 13-acetate (HY-18739) (100 nM) 没有作用[5]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Dapsone-d8 相关抗体:Catalase Antibody (YA552)Catalase Antibody (YA811)MRP2 AntibodyC Reactive Protein Antibody (YA941)Elongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)PARK7/DJ1 Antibody (YA1799)Sulfadimidine Antibody (YA906)C Reactive Protein Antibody (YA939)C Reactive Protein Antibody (YA940)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)PON1 Antibody (YA1666)PON2 Antibody (YA1688)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Anti
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Oxprenolol-d7 hydrochloride，Ba 39089-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Oxprenolol-d7 (hydrochloride) is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oxprenolol-d7 hydrochloride 相关抗体:ADRB2 AntibodySalbutamol Antibody (YA901)Clenbuterol Antibody (YA904)alpha 1a Adrenergic Receptor Antibody (YA2059)分子量：308.85Formula：C15H17D7ClNO3CAS 号：1189649-47-5非标记 CAS：6452-73-9性状：固体颜色：White to off-white中文名称：盐酸氧烯洛尔 d7 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Nortriptyline-d3 hydrochloride，Desmethylamitriptyline-d3 (hydrochloride; Desitriptilina-d3 (hydrochloride「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Nortriptyline-d3 hydrochloride 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：302.86Formula：C19H19D3ClNCAS 号：203784-52-5非标记 CAS：894-71-3性状：固体颜色：White to off-white中文名称：盐酸去甲替林 d3 (盐酸盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture
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Propantheline-d3 bromide，普鲁本辛 d3 (溴盐「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Propantheline-d3 (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Propantheline-d3 bromide 相关抗体:Muscarinic Acetylcholine receptor M3 AntibodyMuscarinic Acetylcholine Receptor M2 Antibody (YA2610)分子量：451.41Formula：C23H27D3BrNO3CAS 号：64717-35-7非标记 CAS：50-34-0性状：固体颜色：Off-white to light yellow中文名称：普鲁本辛 d3 (溴盐)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Curcumin-d6，Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Curcumin-d6is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.IC50 & Target：CBP/p300分子量：374.42Formula：C21H14D6O6CAS 号：1246833-26-0非标记 CAS：458-37-7性状：固体颜色：Yellow to orange中文名称：姜黄素 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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2-Iodoacetamide-d4，Iodoacetamide-d4「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：2-Iodoacetamide-d4 is the deuterium labeled 2-Iodoacetamide[1]. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2-Iodoacetamide-d4 相关抗体:FANCA Antibody (YA2112)FANCD2 Antibody (YA3102)FANCB Antibody (YA2804)分子量：188.99Formula：C2D4INOCAS 号：1219802-64-8非标记 CAS：144-48-9性状：固体颜色：White to off-white中文名称：碘乙酰胺-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Bumetanide-d5，布美他尼 d5「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].分子量：369.45Formula：C17H15D5N2O5SCAS 号：1216739-35-3非标记 CAS：28395-03-1性状：固体颜色：White to off-white中文名称：布美他尼 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Agomelatine-d6，S-20098-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Agomelatine-d6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors[1] .IC50 & Target：MT2MT1分子量：249.34Formula：C15H11D6NO2CAS 号：1079389-42-6非标记 CAS：138112-76-2性状：固体颜色：Off-white to light yellow中文名称：阿戈美拉汀 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Ribociclib-d8，LEE011-d8「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ribociclib-d8 相关抗体:Cyclin E1 Antibody (YA483)CD133 AntibodyCdk2 AntibodyCdk4 AntibodyCdk5 AntibodyCdk6 AntibodyCyclin D3 AntibodyCdk7 AntibodyCDK16 AntibodyCDK5 Antibody (YA796)CDK9 AntibodyCDKN2A/p16INK4a Antibody (YA508)Phospho-CDK1 (Tyr15) AntibodyPhospho-CDK1/2/3 (Thr14) AntibodyPhospho-CDK2 (Tyr15) AntibodyPhospho-Cyclin B1 (Ser126) AntibodyCDKN2A/p16INK4a AntibodyCDKN2C AntibodyPhospho-CDC6 (Ser54) Antibody (YA1017)Cyclin E2 Antibody (YA2594)CDC25C Antibody (YA2624)CDC6 Antibody (YA2626)CDC40 Antibody (YA3168)Cyclin A1/A2 Antibody (YA3336)CRK Antibody (YA790)Cyclin H Antibody (YA788)Cyclin H AntibodyPhospho-CDC6 (Ser106) Antibody (YA1016)CDC7 Antibody (YA1152)Cyclin D3/CCND3 Antibody (YA1201)分子量：442.59Formula：C23H22D8N8OCAS 号：2167898-24-8非标记 CAS：1211441-98-3性状：固体颜色：Off-white to light yellow中文名称：瑞博西尼-d8；瑞柏司可里布-d8运输条件：Room temperature in continental US; may vary elsewhere
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Olanzapine-d3，奥氮平 D3; LY170053-d3「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Olanzapine-d3 is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].IC50 & Target：D3 ReceptormAChR1分子量：315.45Formula：C17H17D3N4SCAS 号：786686-79-1非标记 CAS：132539-06-1性状：固体颜色：White to yellow中文名称：奥氮平 d3；奥兰氮平 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31，1-棕榈酰基-2-油酰基卵磷脂-d3; POPC-d31「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：791.27Formula：C42H51D31NO8PCAS 号：179093-76-6非标记 CAS：26853-31-6性状：固体颜色：White to off-white中文名称：1-棕榈酰基-2-油酰基卵磷脂-d31运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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Nilotinib-d6，AMN107-d6「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Nilotinib-d6 is a deuterium labeled Nilotinib. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity[1].分子量：535.55Formula：C28H16D6F3N7OCAS 号：1268356-17-7非标记 CAS：641571-10-0性状：固体颜色：White to off-white中文名称：尼洛替尼 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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C18-Ceramide-d7「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：C18-Ceramide-d7 is deuterium labeled C18-Ceramide.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.C18-Ceramide-d7 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：573.00Formula：C36H64D7NO3CAS 号：1840942-14-4非标记 CAS：2304-81-6性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Solution, -20°C, 2 years
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Tigecycline-d9，替加环素-d9; GAR-936-d9「同位素标记抑制剂」
作者：德尔塔生物 日期：2025-08-13
生物活性：Tigecycline-d9 is deuterium labeled Tigecycline. Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Tigecycline-d9 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：594.70Formula：C29H30D9N5O8CAS 号：2699607-86-6非标记 CAS：220620-09-7性状：固体颜色：Yellow to orange中文名称：替加环素-d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 97.94%参考文献[1]. Russak EM, et al. Impact of Deuteri
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CAS:1190043-69-6|Naratriptan-d3，GR-85548A-d3-1
作者：德尔塔生物 日期：2025-08-13
生物活性：Naratriptan-d3 (GR-85548A-d3) is the deuterium labeled Naratriptan (HY-B0197). Naratriptan is a selective 5-HT1B/1D receptor agonist. Naratriptan is peripherally active and has good oral bioavailability, inducing cranial artery vasoconstriction by activating 5-HT1B/1D receptors (EC50=0.11 μM for dog basilar artery). Naratriptan also inhibits trigeminal nerve-mediated dural neurogenic plasma extravasation and reduces sterile inflammation. Naratriptan is mainly used in the research of acute migraine, targeting cranial vascular and neuroinflammatory mechanisms[1][2][3][4][5].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物研发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而备受关注[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Naratriptan-d3 相关抗体:MTNR1A Antibody分子量：338.48Formula：C17H22D3N3O2SCAS 号：1190043-69-6非标记 CAS：121679-13-8中文名称：那拉曲坦-d3；纳拉曲坦-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (545 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Rhoden E, et al. Anti-poliovirus activity of protease inhibitor AG-7404, and assessment of in vitro activity in combination with antiviral capsid inhibitor compounds. Antiviral Res. 2013 May;98(2):186-91.
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