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Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation. The compound is a mixture of isomers A ,B , and C .Cancer cell studies show that Oligomycin does not activate the hypoxia-induced factor, however, it enhances the bioenergetic adaptation of heterogeneous bioenergetically organized cells. Oligomycin has been shown to decreased the cyclin D1 protein expression levelsA specific inhibitor of the mitochondrial ATP-synthase. 安全信息 标识符号 GHS07 信号词 Warning 危害声明 H302 警示性声明 P330,P301+P312 WGK 3 //decorateTable('product-attribute-specs-table') 属性 产品名称 寡霉素 产品名称 Oligomycin 别名 Oligomycin 英文别名 Oligomycin a, b, c mixture CAS编号 1404-19-9 分子式 C45H74O11 分子量 791.07(for Oligomycin A) PubChem CID 24898006 MDL号 MFCD00065705 Beilstein 7615308 EC号 MFCD01779388 规格或纯度 92% 应用 A specific inhibitor of the mitochondrial ATP-synthase. 备注 售完停产，不再备货 生化机理 Macrolide antibiotic; inhibits mitochondrial ATPase and phosphoryl group transfer.ATP synthase inhibitor. Blocks the proton channel (F o subunit). Macrolide antibiotic. 熔点 84-100°C 敏感性 对湿度敏感;对光敏感 溶解性 Soluble in EtOH, acetone (50 mg/ml), DMSO (300 mg/ml), ethanol, and methanol. Insoluble in water 储存温度 避光,-20°C储存 运输条件 超低温冰袋运输 品牌 阿拉丁 //decorateTable('product-attribute-specs-table') Alexander RK et al.  et al (2020) Bmal1 integrates mitochondrial metabolism and macrophage activation. Elife(Berl) PMID：32396064 Liu J et al.  et al (2019) CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis. Immunity(Berl) 600-615.e15 PMID：30824325 Kurihara Y et al.  et al (2019) Chlamydia trachomatis targets mitochondrial dynamics to promote intracellular survival and proliferation. Cell Microbiol(Berl) e12962 PMID：30311994 Nakamura-Ishizu A et al.  et al (2018) Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. Cell Rep(Berl) 1772-1785.e6 PMID：30428347 McCarthy RC et al.  et al (2018) Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem(Berl) 7853-7863 PMID：29610275 Sone M et al.  et al (2017) Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab(Berl) 1103-1117.e6 PMID：28467928 Okamoto A et al.  et al (2016) The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. BMC Anesthesiol(Berl) 104 PMID：27776485 Waldeck-Weiermair M et al.  et al (2015) Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca(2.). Sci Rep(Berl) 15602 PMID：26489515 质检报告(COA) 请输入批号: 搜索 傅里叶红外拉曼光谱FT-IR Raman MSDS 点击下载MSDS 质量技术规格说明书 点击查看质控规范 1、名称 2、结构体 3、名称和标识符 4、化学和物理性质 5、光谱信息 6、相关记录 7、药品信息 8、药理与生物化学 9、使用和制造 10、识别 11、安全与危害 12、毒性 13、文献 14、专利权 15、生物分子相互作用和途径 16、生物测试结果 17、分类 18、信息来源 19、GHS分类 20、CAS编号 21、EC号 22、GHS分类摘要 23、危险等级象形图 24、GHS危险说明 25、防范说明 26、欧盟危险声明 27、SWA危险说明