【产品介绍】：

 PD-123319 分子式：C31H32N4O3   分子量：508.61 产品描述 PD 123319是有效的，选择性AT2血管紧张素Ⅱ受体拮抗剂，IC50 为34 nM。 靶点 AT2 angiotensin II receptor           IC50 34 nM           体外研究 PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125I-AII specifically labeled two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM). 体内研究 PD 123319 has no effect on cerebral blood flow autoregulation. Acute AT2-receptor blockade does not influence CBF autoregulation.Intravenous administration of PD 123319 to conscious hypertensive rats elicites an immediate dose-dependent increase in MAP that is sustained for approximately 7.4 min with 3 mg/kg PD 123319. [4] - See more at: http://www.selleckchem.com/products/pd123319.html#sthash.AZDud0GK.dpuf 溶解性 DMSO 100 mg/mL，水 100 mg/mL，乙醇 100 mg/mL 稳定性 2年 -20°C粉状，6月-80°C溶于DMSO 特征       运输条件：2~8℃运输 我司所售出产品仅供于科研研究用途（非临床科研研究），每次销售产品行为都适用于我司网上所列明的通用销售条款。 CAS 号：130663-39-7 英文名字：PD-123319 质量标准：>98%,BR 分子式：C31H32N4O3