【产品介绍】：

产品介绍：Clemizole is a potent anti-allergic drug. Clemizole hydrochloride 是一种 H1 组胺受体 (H1 histamine receptor) 拮抗剂，抑制 HCV 复制。 安全信息 RTECS DD6730000 属性 产品名称 克立咪唑 盐酸盐 产品名称 Clemizole hydrochloride 别名 1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑 盐酸盐，盐酸克立咪唑；1-(4-氯苄基)-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐 英文别名 1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride；1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride，1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride；CID 2782 hydrochloride；NSC 46261； CAS编号 1163-36-6 分子式 C19H21Cl2N3 分子量 362.3 PubChem CID 5309446 MDL号 MFCD00051435 Merck Index 2346 规格或纯度 98% (HPLC) 生化机理 Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment. Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture. 熔点 241 °C 敏感性 对 热、空气敏感 溶解性 H2O: 2 mg/mL, clear (warmed)，≥15.13 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.12 mg/mL in DMSO; ≥5.12 mg/mL in H2O with gentle warming and ultrasonic 储存温度 -20°C储存,充氩 运输条件 超低温冰袋运输