【产品介绍】：

Plerixafor 8HCl (AMD3100 8HCl)是Plerixafor的盐酸盐，是CXCR4趋化因子受体拮抗剂，作用于CXCR4和CXCL12调节的趋化性， IC50分别为44 nM和5.7 nM。A specific CXCR4 antagonist. 属性 产品名称 Plerixafor 8HCl (AMD3100 8HCl) 产品名称 Plerixafor 8HCl (AMD3100 8HCl) 别名 普乐沙福八盐酸盐；1,4-双[(1,4,8,11-四氮杂环十四烷-1-基)甲基]苯八盐酸盐；1,1'-[1,4-亚苯基双(亚甲基)]双-1,4,8,11-四氮杂环十四烷八盐酸盐 英文别名 AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;1,1′-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride CAS编号 155148-31-5 分子式 C28H54N8·8HCl 分子量 794.47 PubChem CID 65014 MDL号 MFCD04974488 规格或纯度 ≥99% 应用 A specific CXCR4 antagonist. 备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 生化机理 AMD3100 octahydrochloride is a selective bicyclam derivative which functions as a stem cell mobiliser via blocking the CXCR4 chemokine receptor. Studies sμggest that AMD3100 octahydrochloride causes the rapid movement of stem cells out of bone marrow via blocking the CXCR4 receptor. Since the CXCR4 receptor is responsible for regulating metastasis in chemoresistant melanoma cells, blocking this receptor can possibly reduce the metastasis of melanoma cells. In addition, studies indicate that AMD3100 octahydrochloride can inhibit the replication of human immunodeficiency virus in vitro by blocking the entry of the virus into cells. Furthermore, AMD3100 octahydrochloride can also reduce the number of human CD4+ T cells.Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF- 1 (CXCL12). It suppresses infection by HIV with an IC 50 value of 1- 10 ng/ml with selectivity toward CXCR4- t 熔点 245 °C 敏感性 对热敏感 溶解性 DMSO Water 100 mg/mL Ethanol 储存温度 -20°C储存 运输条件 超低温冰袋运输 Umezu K et al.  et al (2020) Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle. PLoS One(Berl) e0232536 PMID：32353075 Zeng Y et al.  et al (2019) Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J(Berl) 6596-6608 PMID：30802149 Ding Q et al.  et al (2019) Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages. 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