【产品介绍】：

中文别名 奥法木单抗 英文别名 Ofatumumab CAS号 679818-59-8 SMILES Inchi InchiKey 分子式 Formula 分子量 Molecular Weight 闪点 FP NA 熔点 Melting point NA 沸点 Boiling point NA Polarizability极化度 密度 Density NA 蒸汽压 Vapor Pressure 溶解度Solubility 性状 Liquid 储藏条件 Storage conditions Ofatumumab使用注意事项：1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害。3.取样品的移液枪头需及时更换，必要时为避免交叉污染尽可能选择滤芯吸头。4.称量药品时选用称量纸，并无风处取药和称量以免扬撒，试剂的容器使用前务必确保干净，并消毒。5.取药品时尽量采用多个药勺分别使用，使用后清洗干净。6.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染。大规格定制：定制产品请将信息发送至sales@bio-fount.com。Experimental considerations: 1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment. 2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution. 产品说明 Organic Acids IntroductionSelectively targets cancer cells expressing mutant epidermal growth factor receptor (EGFR) vIII or over expressing wild type EGFR1. Depatuxizumab mafodotin acts on these cells to inhibit microtuble polymerization thus disrupting mitosis and vesicular trafficking2 Application1CD20 is expressed on normal pre-B lymphocytes and mature B lymphocytes, as well as malignant B lymphocytes. Numerous studies demonstrate that the depletion of B-cells can significantly alleviate symptoms of many forms of leukemia and lymphoma, which are malignancies associated with B-cell dysfunctions and high expression of CD20.4Ofatumumab is an anti-CD20 monoclonal antibody that binds to the small and large extracellular loops of the CD20 molecule. The Fab domain of ofatumumab binds to CD20, and this drug-target interaction does not result in immediate shedding and internalization of CD20 from the plasma membrane of B lymphocytes.2,6This allows ofatumumab to persist on the B lymphocyte cell surface for an extended period and recruit immunological molecules or FcR-expressing innate effectors, such as macrophages, that mediate immune effector functions with strong cytotoxic effects.2,4These immune effector functions include complement-dependent cytotoxicity (CCD) and antibody-dependent cellular cytotoxicity (ADCC), which promote the lysis of malignant B-cells.2,4,6Complement-dependent cytotoxicity (CDC) involves translocation of the CD20 molecule into lipid rafts, which are involved in cell signalling and receptor trafficking.1TargetActionsOrganismAB-lymphocyte antigen CD20antibodyHumans Application2 Application3 警示图 危险性 危险性警示 warning 安全声明 安全防护 备注 实验过程中防止吸入、食如，做好安全防护 对不起，暂无产品评价！