【产品介绍】：

Name:Sodium dichloroacetate (DCA)
Synonyms:Dichloroacetic acid, bichloroacetic acid, BCA
CAS Number:2156-56-1
Formula:C2HCl2O2.Na
M.w.:150.92
DMSO (mg/mL)Max Solubility:30
DMSO (mM)Max Solubility:198.78
Form:sodium salt
SMILES:[Na]OC(=O)C(Cl)Cl
ALogP:1.081
Target:Apoptosis related,Dehydrogenase,NKCC,ROS
Pathway:Metabolism
Information:Sodium dichloroacetate (DCA, Dichloroacetic acid, bichloroacetic acid, BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
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