【产品介绍】：

Name:ML141
Synonyms:CID-2950007
CAS Number:71203-35-5
Formula:C22H21N3O3S
M.w.:407.49
DMSO (mg/mL)Max Solubility:81
DMSO (mM)Max Solubility:198.78
Form:free base
SMILES:COC1=CC=C(C=C1)C2CC(=NN2C3=CC=C(C=C3)[S](N)(=O)=O)C4=CC=CC=C4
ALogP:3.87
Target:Apoptosis related,p38 MAPK,Rho
Pathway:Cell Cycle
Information:ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
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