【产品介绍】：

Name:Remibrutinib (LOU064)
Synonyms:N/A
CAS Number:1787294-07-8
Formula:C27H27F2N5O3
M.w.:507.53
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:197.03
Form:free base
SMILES:CN(CCOC1=C(N=CN=C1N)C2=C(C)C(=CC(=C2)F)NC(=O)C3=C(F)C=C(C=C3)C4CC4)C(=O)C=C
ALogP:4.374
Target:BTK,Interleukins
Pathway:Angiogenesis
Information:Remibrutinib (LOU064) is a potent, highly selective covalent inhibitor of bruton tyrosine kinase (BTK) with IC50 of 1.3 nM, 2.5 nM and 18 nM for BTK, FcγR-induced IL8 and anti-IgM/IL4-induced CD69, respectively. Remibrutinib (LOU064) exhibits an exquisite kinase selectivity due to binding to an inactive conformation of BTK and has the potential for the treatment of autoimmune diseases.
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