【产品介绍】：

生物活性：Rapamycin-13C,d3 (Sirolimus-13C,d3; AY-22989-13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219)[1].Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant[1][2].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Rapamycin-13C,d3 相关抗体:
Phospho-mTOR (Ser2448) Antibody (YA171)
mTOR Antibody (YA281)
RHEB Antibody
FKBP12 Antibody
FKBP51 Antibody
FKBP52 Antibody
Phospho-mTOR (Ser2448) Antibody (YA691)
Hamartin Antibody
4E BP1 Antibody
mTOR Antibody
Phospho-4E BP1 (Thr46) Antibody
Phospho-mTOR (Ser2481) Antibody
Raptor Antibody (YA1519)
FKBP38 Antibody (YA2803)
RICTOR Antibody
4E BP2 Antibody (YA1079)
4E BP3 Antibody (YA1080)
FKBP6 Antibody (YA2920)
Tuberin Antibody (YA3037)
分子量：918.18
Formula：C5013CH76D3NO13
非标记 CAS：53123-88-9
性状：固体
颜色：White to off-white
中文名称：雷帕霉素-13C,d3；西罗莫司-13C,d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, protect from light, stored under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
纯度 & 产品资料
纯度： 97.05%
参考文献
[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.
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[2]. Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.
 [Content Brief]