【产品介绍】：

生物活性：Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Nintedanib-d3 相关抗体:
FGFR2/CD332 Antibody
Phospho-PDGFR beta (Y740) Antibody
VEGF Receptor 2 Antibody (YA014)
FGFR1 Antibody
FGFR1 Oncogene Partner Antibody
FGFR2 Antibody
FGFR3 Antibody
PDGFR alpha Antibody
FGF2 Antibody
VEGF Receptor 1 Antibody
VEGFA Antibody
VEGF Receptor2 Antibody
FGF1 Antibody (YA1430)
PDGF B Antibody (YA1556)
FGFR4 Antibody (YA1588)
PLGF Antibody (YA1812)
PDGFR beta Antibody (YA1925)
VEGFD Antibody (YA2385)
FGF19 Antibody (YA2672)
TACC3 Antibody (YA2921)
Phospho-PDGFR beta (Tyr740) Antibody (YA3062)
FGF21 Antibody (YA3276)
PGF Antibody (YA1434)
Neuropilin 1 Antibody (YA1831)
VEGFB Antibody (YA2627)
分子量：542.64
Formula：C31H30D3N5O4
CAS 号：1624587-84-3
非标记 CAS：656247-17-5
中文名称：尼达尼布 d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782.
 [Content Brief]
[3]. Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480.
 [Content Brief]