【产品介绍】：

生物活性：Fenbufen-d9 (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Fenbufen-d9 相关抗体:
Cleaved-Caspase 9 Antibody
Cleaved-Caspase 1 Antibody
Cleaved-Caspase 3 p12 Antibody
Caspase-3 Antibody
Caspase-9 Antibody
COX2 Antibody
Caspase 7 Antibody
Caspase-10 Antibody
Caspase-14 Antibody
Caspase-6 Antibody
Caspase-6 p18 Antibody
Caspase-8 Antibody
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
Carbonic Anhydrase I Antibody
CARD9 Antibody
Caspase 1 Antibody
Caspase 11 Antibody
Cleaved-Caspase 8 Antibody
COX IV Antibody (YA867)
Caspase-12 Antibody
Caspase-1 Antibody
CASP4 Antibody
Caspase-5 p20 Antibody
APAF1 Antibody (YA1481)
NOXA2 Antibody (YA1649)
DKC1 Antibody (YA1750)
Cyclooxygenase 1 Antibody (YA2537)
Cyclooxygenase 2 Antibody (YA2541)
FADD Antibody (YA2793)
分子量：263.34
Formula：C16H5D9O3
CAS 号：1189940-96-2
非标记 CAS：36330-85-5
中文名称：芬布芬 d9
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. A E Sloboda, et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung. 1980;30(4A):716-21.
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[3]. R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr;66(4):466-76.
 [Content Brief]
[4]. A E Sloboda, et al. The pharmacology of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec;1(4):415-38.
 [Content Brief]
[5]. Asif Husain, et al. Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep;44(9):3798-804.
 [Content Brief]
[6]. Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24(3):281-292.
 [Content Brief]