【产品介绍】：

生物活性：Mifepristone-13C,d3 is the 13C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[80].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Mifepristone-13C,d3 相关抗体:
iNOS Antibody
Glucocorticoid Receptor alpha Antibody
nNOS Antibody
eNOS Antibody
Glucocorticoid Receptor Antibody
Phospho-eNOS (Ser1177) Antibody
DDAH2 Antibody (YA1447)
Progesterone Receptor Antibody (YA1866)
Phospho-Glucocorticoid Receptor (Ser226) Antibody (YA2595)
Phospho-Progesterone Receptor (Ser190) Antibody (YA1736)
DDAH1 Antibody (YA2661)
GMEB1 Antibody (YA2942)
分子量：433.60
Formula：C2813CH32D3NO2
非标记 CAS：84371-65-3
中文名称：米非司酮-13C,d3；美服培酮-13C,d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
 [Content Brief]
[2]. Jiang W, et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14(19):6726-32.
 [Content Brief]
[3]. Jurado R, et al. NSC 119875 cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22(5):1237-45.
 [Content Brief]
[4]. Sharrett-Field L, et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23.
 [Content Brief]
[5]. Yuehua You, et al. Progesterone Promotes Endothelial Nitric Oxide Synthase Expression Through Enhancing Nuclear Progesterone receptor-SP1 Formation. Am J Physiol Heart Circ Physiol. 2020 Jul 3.
 [Content Brief]