【产品介绍】：

生物活性：UMI-77-d4 is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
UMI-77-d4 相关抗体:
Bcl-2 Antibody
Bcl2 Antibody
Bax Antibody (YA591)
Bad Antibody
Bak Antibody (YA592)
BAX Antibody (YA825)
Bcl-XL Antibody
Bim Antibody
BNIP3 Antibody
PUMA Antibody
MCL1 Antibody
Bak Antibody
Bax Antibody (YA826)
Bcl2 Antibody (YA824)
BNIP3L Antibody
BAG2 Antibody (YA1398)
Phospho-PML Protein (Ser518) Antibody (YA2632)
Bid Antibody
BAG1 Antibody (YA932)
BAG1 Antibody (YA933)
Bcl10 Antibody (YA1188)
BAP31 Antibody (YA1320)
BCL2L1 Antibody (YA1359)
BAG3 Antibody (YA2240)
Bok Antibody (YA2289)
BPR Antibody (YA2393)
DYNLL1 Antibody (YA2724)
Bcl2 L14 Antibody (YA2740)
Bcl2 A1 Antibody (YA2743)
Phospho-Bad (Ser112) Antibody (YA3099)
分子量：472.37
Formula：C18H10D4BrNO5S2
非标记 CAS：518303-20-3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Abulwerdi F, et al. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2014 Mar;13(3):565-575.
 [Content Brief]