【产品介绍】：

生物活性：Etifoxine-d5 is the deuterium labeled Etifoxine. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Etifoxine-d5 相关抗体:
GABARAP Antibody
IP3 Receptor Antibody (YA1596)
GABA B Receptor 2 Antibody (YA1733)
GABA B Receptor 1 Antibody (YA2418)
GAD65 Antibody (YA758)
GABA A Receptor alpha 1 Antibody (YA1315)
GABA A Receptor beta 2 Antibody (YA1758)
GABA Transporter 1 Antibody (YA1795)
GAD67 Antibody (YA1807)
ABAT Antibody (YA1964)
GABA A Receptor alpha 5 Antibody (YA2249)
GABA A Receptor beta 1 Antibody (YA2261)
BGAT Antibody (YA2741)
GABARAPL2 Antibody (YA2882)
分子量：305.81
Formula：C17H12D5ClN2O
CAS 号：1346598-10-4
非标记 CAS：21715-46-8
中文名称：艾替伏辛-d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Marc Verleye, et al. Effects of etifoxine on ligand binding to GABA(A) receptors in rodents. Neurosci Res. 2002 Oct;44(2):167-72.
 [Content Brief]
[3]. Alain Hamon, et al. The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit. Neuropharmacology. 2003 Sep;45(3):293-303.
 [Content Brief]
[4]. Marc Verleye, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;21(6):457-70.
 [Content Brief]