【产品介绍】：

生物活性：Inosine-13C is the 13C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
Inosine 剂量依赖性地刺激通过 A2AR 介导的 cAMP 产生[3]。
Inosine 剂量依赖性地诱导 hA2AR 介导的 ERK1/2 磷酸化[3]。
Inosine (100 μM；24 小时) 可降低与星形胶质细胞一起培养的 MES 23.5 细胞中的氧化应激[4]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Inosine-13C 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
GAPDH Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
METTL3 Antibody
TSG101 Antibody
Alkaline Phosphatase Antibody
Calnexin Antibody (YA573)
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
OPA1 Antibody
RBM3 Antibody
Synaptophysin Antibody (YA043)
Laminin beta 1 Antibody
Heme Oxygenase 1 Antibody
Ki67 Antibody (YA717)
Ki67 Antibody (YA322)
Asparagine Synthetase Antibody
Calnexin Antibody
Ki67 Antibody (YA001)
Osteopontin Antibody
Synaptophysin Antibody (YA664)
TREM2 Antibody
GAPDH Antibody (YA848)
分子量：269.21
Formula：C913CH11N4O5
非标记 CAS：58-63-9
中文名称：肌苷-13C； 次黄苷-13C
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (544 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Filipe Marques Gonçalves, et al. Signaling pathways underlying the antidepressant-like effect of inosine in mice. Purinergic Signal. 2017 Jun; 13(2): 203-214.
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[2]. Francisney Pinto Nascimento, et al. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Mol Neurobiol. 2015;51(3):1368-78.
 [Content Brief]
[3]. Ajith A. Welihinda, et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun; 28(6): 552-560.
 [Content Brief]
[4]. Sara Cipriani, et al. Protection by inosine in a cellular model of Parkinson’s disease. Neuroscience. 2014 Aug 22; 274: 242-249.
 [Content Brief]