【产品介绍】：

生物活性：Fluorofenidone-d3 is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Fluorofenidone-d3 相关抗体:
Phospho-AKT1 (Ser473) Antibody
AKT1/2/3 Antibody (YA633)
Phospho-AKT (Thr308) Antibody
Phospho-AKT1(Ser473) Antibody
PI3 Kinase p110 gamma Antibody (YA690)
AKT1 Antibody (YA834)
AKT1 Antibody (YA634)
CD41 Antibody
CD19 Antibody (YA543)
Hamartin Antibody
PI 3 Kinase p85 alpha Antibody
AKT1/AKT2/AKT3 Antibody (YA635)
CD19 Antibody (YA807)
Lyn Antibody (YA707)
Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody
PI3 Kinase p55 gamma Antibody
PI3 Kinase p85 alpha Antibody (YA689)
PI3 Kinase p85 beta Antibody (YA688)
PI3 Kinase p110 alpha/PIK3CA Antibody (YA3537)
phospho-PI3 Kinase p110 beta (Ser1070) Antibody
TRIB3 Antibody (YA2174)
PIK3C3 Antibody (YA2789)
PI 3 Kinase p150 Antibody (YA2823)
PDPK1 Antibody (YA1569)
PI3 Kinase p110 delta Antibody (YA1617)
AS160 Antibody (YA2170)
MPP1 Antibody (YA3077)
分子量：206.23
Formula：C12H7D3FNO
非标记 CAS：848353-85-5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9.
 [Content Brief]
[3]. Lou Q, et al. Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones. Molecules. 2012 Jan 17;17(1):884-96.
 [Content Brief]