【产品介绍】：

生物活性：Dapsone-13C12 is the 13C12 labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Dapsone-13C12 相关抗体:
Catalase Antibody (YA552)
Catalase Antibody (YA811)
MRP2 Antibody
C Reactive Protein Antibody (YA941)
Elongation factor 2 Antibody (YA962)
Elongation factor 2 Antibody (YA964)
PU.1/SPI1 Antibody (YA1116)
PARK7/DJ1 Antibody (YA1799)
Sulfadimidine Antibody (YA906)
C Reactive Protein Antibody (YA939)
C Reactive Protein Antibody (YA940)
Elongation factor 2 Antibody (YA963)
Anthrax Protective gen Antibody (YA1060)
PON1 Antibody (YA1666)
PON2 Antibody (YA1688)
Elongation factor 1 gamma Antibody (YA2004)
Pulmonary Surfactant Associated Protein D Antibody (YA2107)
Cathelicidin Antibody (YA2380)
Elongation Factor Ts Antibody (YA2524)
Elongation Factor 1A2 Antibody (YA2879)
BPI Antibody (YA3068)
MetRS Antibody (YA3196)
分子量：260.21
Formula：13C12H12N2O2S
CAS 号：1632119-29-9
非标记 CAS：80-08-0
中文名称：氨苯砜-13C12；二氨基二苯砜-13C12；达普松-13C12
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (540 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]
[2]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol
 [Content Brief]
[3]. Dapsone, Drug.com
[4]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.
 [Content Brief]
[5]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.
 [Content Brief]