【产品介绍】：

生物活性：Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Maraviroc-d6 相关抗体:
CCR2 Antibody
CD4 Antibody
CCR7 Antibody
MCP1 Antibody
TARBP2 Antibody (YA1433)
SAMHD1 Antibody (YA1542)
CCL21 Antibody (YA2775)
SV40 T Antigen Antibody (YA3256)
TARC/CCL17 Antibody (YA1211)
CCR6 Antibody (YA1291)
CCR8 Antibody (YA1373)
CLEC12A Antibody (YA1419)
CCL19 Antibody (YA1670)
CCL4 beta Antibody (YA2559)
Tat SF1 Antibody (YA2886)
CCL19 beta Antibody (YA2923)
CCL23 Antibody (YA2929)
CCR9 Antibody (YA3119)
分子量：519.70
Formula：C29H35D6F2N5O
CAS 号：1033699-22-7
非标记 CAS：376348-65-1
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (527 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472
 [Content Brief]
[3]. Mencarelli A, et al. Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep. 2016 Aug 5;6:30802.
 [Content Brief]
[4]. Romero-Sánchez MC, et al. Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother. 2012 Nov;56(11):5858-64.
 [Content Brief]
[5]. Huilin Mou, et al. NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses. Journal of Drug Metabolism & Toxicology. January 10, 2016.