【产品介绍】：

生物活性：Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Glipizide-d11 相关抗体:
ATP1A1 Antibody
LGI1 Antibody (YA2885)
Cardiac Troponin C Antibody (YA2125)
Cardiac Troponin T Antibody (YA2719)
SAP97 Antibody (YA2731)
Kir2.1 Antibody (YA2871)
分子量：456.60
Formula：C21H16D11N5O4S
CAS 号：1189426-07-0
非标记 CAS：29094-61-9
性状：固体
颜色：White to light brown
中文名称：格列吡嗪 d11
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month
纯度 & 产品资料
纯度： 96.36%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. B J Zünkler, et al. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337(2):225-30.
 [Content Brief]
[3]. Glipizide. From Wikipedia