【产品介绍】：

FH535能双重抑制Wnt/beta-catenin和PPAR信号通路A cell-permeable compound that inhibits Wnt/β-catenin and PPAR 属性 产品名称 FH535 产品名称 FH535 别名 FH 535;FH-535 英文别名 FH 535;FH-535；2,5-dichloro-n-(2-methyl-4-nitrophenyl)benzenesulfonamide；N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide CAS编号 108409-83-2 分子式 C13H10Cl2N2O4S 分子量 361.2 PubChem CID 3463933 规格或纯度 ≥98% 应用 A cell-permeable compound that inhibits Wnt/β-catenin and PPAR 备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 生化机理 Description:IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1] FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand-dependent activation and shows structural similarity to GW9662, a known PPAR gamma antagonist.in vitro:  FH535 significantly inhibited cell migration of Mel 1241 cells, which was associated with the elevated levels of casein kinase 1α and glycogen synthase kinase-3β, and decreased accumulation of nuclear β-catenin and inhibition of MMP-2 and MMP-9 levels [2].  FH535 was shown to increase CSC-induced cytotoxicity and depress β-catenin expression. However, FH535 effects were not limited to the β-catenin pathway as it also blocked the expression of early growth responsive protein 1 (EGR-1) target genes, fibronectin and phosphatase and tensin homologue, without affecti.Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro . Antitumor agent. 沸点 ~526.3° C at 760 mmHg 熔点 202.89°C 折光率 1.65 溶解性 25°C: DMSO 储存温度 2-8°C储存 运输条件 冰袋运输 密度 1.6 Delta生物试剂 Adenosine 下载 G PROTEIN-COUPLED RECEPTORS 下载 IP3 receptor 下载 Adrenoceptors, a1 下载 Adrenoceptors, a2 下载 Adrenoceptors, β 下载 GABAA (γ-aminobutyric acid) 下载 GABAB 下载 Calcium (voltage-gated) 下载 Phosphodiesterases 下载 Phosphoinositide Kinases 下载 Phospholipase A2 下载 Phospholipase C 下载 Phospholipase D 下载 Phosphoprotein Phosphatases 下载 Platelet-Activating Factor Receptors 下载 Protein Prenyltransferases 下载 Steroids Receptors 下载 Protein tyrosine phosphatases 下载 G Proteins (Heterotrimeric) 下载 Caspases 下载 Nitric Oxide Synthases 下载 Nonsteroidal Receptors 下载 Peroxisome proliferator activated receptors 下载 Ryanodine Receptors 下载 Adenylyl Cyclase 下载 GTP Binding Proteins 下载 Adenosine 下载 G PROTEIN-COUPLED RECEPTORS 下载 IP3 receptor 下载 Adrenoceptors, a1 下载 Adrenoceptors, a2 下载 Adrenoceptors, β 下载 GABAA (γ-aminobutyric acid) 下载 GABAB 下载 Calcium (voltage-gated) 下载 Phosphodiesterases 下载 Phosphoinositide Kinases 下载 Phospholipase A2 下载 Phospholipase C 下载 Phospholipase D 下载 Phosphoprotein Phosphatases 下载 Platelet-Activating Factor Receptors 下载 Protein Prenyltransferases 下载 Steroids Receptors 下载 Protein tyrosine phosphatases 下载 G Proteins (Heterotrimeric) 下载 Caspases 下载 Nitric Oxide Synthases 下载 Nonsteroidal Receptors 下载 Peroxisome proliferator activated receptors 下载 Ryanodine Receptors 下载 Adenylyl Cyclase 下载 GTP Binding Proteins 下载 Adenosine 下载 G PROTEIN-COUPLED RECEPTORS 下载 IP3 receptor 下载 Adrenoceptors, a1 下载 Adrenoceptors, a2 下载 Adrenoceptors, β 下载 GABAA (γ-aminobutyric acid) 下载 GABAB 下载 Calcium (voltage-gated) 下载 Phosphodiesterases 下载 Phosphoinositide Kinases 下载 Phospholipase A2 下载 Phospholipase C 下载 Phospholipase D 下载 Phosphoprotein Phosphatases 下载 Platelet-Activating Factor Receptors 下载 Protein Prenyltransferases 下载 Steroids Receptors 下载 Protein tyrosine phosphatases 下载 G Proteins (Heterotrimeric) 下载 Caspases 下载 Nitric Oxide Synthases 下载 Nonsteroidal Receptors 下载 Peroxisome proliferator activated receptors 下载 Ryanodine Receptors 下载 Adenylyl Cyclase 下载 GTP Binding Proteins 下载