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「同位素标记抑制剂」CAS:222295-76-3|Cyclosporin A-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cyclosporin A-d3 相关抗体:Albumin AntibodyCD46 AntibodyPFKFB3 AntibodyC3 AntibodyDUSP1 AntibodyDUSP3 AntibodyC5b-9 AntibodyIntestinal Alkaline Phosphatase Antibody (YA1559)PFKL Antibody (YA1597)SHP2 Antibody (YA1643)PP1C alpha/beta Antibody (YA1700)PTP1B Antibody (YA1776)PLEKHA1 Antibody (YA2145)PGAM1 Antibody (YA2156)DUSP6 Antibody (YA2280)PRAS40 Antibody (YA3179)Annexin A2 AntibodyPPP4C Antibody (YA687)Phospho-PTP1B (Ser352) Antibody (YA1027)Phospho-PTP1B (Ser378) Antibody (YA1028)Placental Alkaline Phosphatase Antibody (YA1038)Placental Alkaline Phosphatase Antibody (YA1039)PP1C alpha Antibody (YA1040)PP1C alpha Antibody (YA1041)SHP1 Antibody (YA1044)SHP1 Antibody (YA1045)PP1C gamma Antibody (YA1068)PPP5C Antibody (YA1069)INPP4B Antibody (YA1236)PPM1G Antibody (YA1698)分子量：1205.63Formula：C62H108D3N11O12CAS 号：222295-76-3非标记 CAS：59865-13-3中文名称：环孢霉素A-d3；环孢素A-d3；环孢多肽A-d3；环孢灵-d3；赛斯平-d3；环孢素-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analy
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「同位素标记抑制剂」CAS:2748541-63-9|Triflusal-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Triflusal-d3 is deuterium labeled Triflusal.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Triflusal-d3 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：251.17Formula：C10H4D3F3O4CAS 号：2748541-63-9非标记 CAS：322-79-2中文名称：三氟柳-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (530 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Fernández de Arriba A, et al. Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid. Mol Pharmacol. 1999 Apr;55(4):753-60. [Content Brief][3]. Duran, X., et al., Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. J Thromb Haemost, 2008. 6(8): p. 1385-92. [Content Brief][4]. De Miguel, L.S., et al., A 4-trifluo
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「同位素标记抑制剂」CAS:1329496-63-0|Maprotiline-d3 hydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：Maprotiline-d3 (hydrochloride) is deuterium labeled Maprotiline (hydrochloride).体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Maprotiline-d3 hydrochloride 相关抗体:FOXO1A AntibodyBeclin 1 AntibodyAtg12 AntibodyATG5 AntibodyBmi1 AntibodyFOXO4 AntibodyFOXP3 AntibodyGABARAP AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyPhospho-FOXO3a(Ser253) AntibodyAPG5L AntibodyATG10 Antibody (YA603)ATG3 AntibodyATG4A AntibodyATG4C AntibodyATG7 AntibodyFOXO1 Antibody (YA430)FOXO3 AntibodyFOXP3 Antibody (YA759)FTO AntibodyPhospho-FOXO3A (Ser253) AntibodyFOXO1 AntibodyATG10 AntibodyGranulin Antibody (YA1162)ATG13 Antibody (YA1650)ATG9A Antibody (YA3081)LAMP2 Antibody (YA310)WIPI1 Antibody (YA1721)ATG16L1 Antibody (YA2187)分子量：316.88Formula：C20H21D3ClNCAS 号：1329496-63-0非标记 CAS：10347-81-6性状：固体颜色：White to off-white中文名称：盐酸马普替林-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1356383-38-4|Captopril-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Captopril-d3 is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Captopril-d3 相关抗体:ACE2 AntibodyACE AntibodyACE Antibody (YA2094)分子量：220.30Formula：C9H12D3NO3SCAS 号：1356383-38-4非标记 CAS：62571-86-2中文名称：卡托普利-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [Content Brief][3]. Esmaeili S, et al. Captopril/enalapril inhibit promisc
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「同位素标记抑制剂」CAS:2702733-53-5|Azathioprine-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1].Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT01284725Assistance Publique Hopitaux De MarseilleNephritis of LupusJanuary 2011Phase 3NCT01802593Prof. Arie Levine|Wolfson Medical CenterCrohn´s DiseaseFebruary 2013Phase 4NCT00377637Hoffmann-La Roche|Aspreva PharmaceuticalsLupus NephritisJuly 2005Phase 3 NCT03393247Sixth Affiliated Hospital, Sun Yat-sen UniversityCrohn DiseaseJune 1, 2017Not ApplicableNCT03498703Ain Shams University|Capital Birth CenterRecurrent Implantation Failure|In Vitro Fertilization|Intracytoplsmic Sperm InjectionApril 25, 2018Phase 2NCT00987116Assistance Publique - Hôpitaux de ParisMyasthenia GravisJune 2009Phase 4NCT03930264Nova Laboratories Limited|Medicines Evaluation Unit Ltd|Syne Qua Non Limited|Alderley Analytical Ltd|Black County Pathology Services|Diamond Pharma Services Regulatory Affairs Consultancy|Boyd ConsultantsTherapeutic EquivalencyApril 11, 2019Phase 1NCT00976690Groupe d´Etude Therapeutique des Affections Inflammatoires DigestivesCrohn DiseaseOctober 2002Phase 3NCT01663623Human Genome Sciences Inc., a GSK Company|GlaxoSmithKlineVasculitisMarch 20, 2013Phase 3NCT02645565Jawaharlal Institute of Postgraduate Medical Education & ResearchLupus NephritisDecember 2015Phase 4NCT05813860Sixth Affiliated Hospital, Sun Yat-sen
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「同位素标记抑制剂」CAS:1432057-38-9|Ramelteon-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Ramelteon-d3 is a deuterium-labelled Ramelteon (HY-A0014).分子量：262.36Formula：C16H18D3NO2CAS 号：1432057-38-9非标记 CAS：196597-26-9性状：固体颜色：White to off-white中文名称：雷美替胺-d3；瑞美替昂-d3；拉米替隆-d3；雷美尔通-d3；瑞美替胺-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1190043-13-0|Alosetron-d3
作者：德尔塔生物 日期：2025-06-12
生物活性：Alosetron-d3 is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].分子量：297.37Formula：C17H15D3N4OCAS 号：1190043-13-0非标记 CAS：122852-42-0中文名称：阿洛司琼-d3；洛曲尼斯-d3；罗肠兴-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Harris LA, et al. Alosetron: an effective treatment for diarrhea-predominant irritable bowel syndrome. Womens Health (Lond). 2007 Jan;3(1):15-27. [Content Brief]
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「同位素标记抑制剂」CAS:2734919-98-1|Moxifloxacin-d3 hydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：Moxifloxacin-d3 (hydrochloride) is the deuterium labeled Moxifloxacin hydrochloride. Moxifloxacin hydrochloride is an orally active 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia[1][2][3].IC50 & Target：Quinolone体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Moxifloxacin-d3 hydrochloride 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：440.91Formula：C21H22D3ClFN3O4CAS 号：2734919-98-1非标记 CAS：151096-09-2中文名称：盐酸莫西沙星-d3；莫西沙星盐酸盐-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (5
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「同位素标记抑制剂」CAS:1219804-76-8|Linuron-d6
作者：德尔塔生物 日期：2025-06-12
生物活性：Linuron-d6 is the deuterium labeled 3-Bromo-L-tyrosine[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Linuron-d6 相关抗体:Androgen receptor AntibodyPOMC Antibody (YA1619)分子量：255.13Formula：C9H4D6Cl2N2O2CAS 号：1219804-76-8非标记 CAS：330-55-2中文名称：利谷隆-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]
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「同位素标记抑制剂」CAS:2748492-38-6|Cyclobenzaprine-d6 hydrochloride
作者：德尔塔生物 日期：2025-06-12
生物活性：Cyclobenzaprine-d6 (hydrochloride) is deuterium labeled Cyclobenzaprine (hydrochloride).体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cyclobenzaprine-d6 hydrochloride 相关抗体:MTNR1A Antibody分子量：317.89Formula：C20H16D6ClNCAS 号：2748492-38-6非标记 CAS：6202-23-9中文名称：阿米替林EP杂质B-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (525 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Kobayashi, H., Y. Hasegawa, and H. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35. [Content Brief][3]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9. [Content Brief]
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「同位素标记抑制剂」CAS:110510-78-6|1-Decanol-d21
作者：德尔塔生物 日期：2025-06-11
生物活性：1-Decanol-d21 is the deuterium labeled 1-Decanol[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：179.41Formula：C10HD21OCAS 号：110510-78-6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (521 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:1398065-76-3|Heptyl methyl ketone-d5
作者：德尔塔生物 日期：2025-06-11
生物活性：Heptyl methyl ketone-d5 is the deuterium labeled Heptyl methyl ketone[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Heptyl methyl ketone-d5 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：147.27Formula：C9H13D5OCAS 号：1398065-76-3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (515 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:33675-83-1|Acetamide-d5
作者：德尔塔生物 日期：2025-06-11
生物活性：Acetamide-d5 is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：64.10Formula：C2D5NOCAS 号：33675-83-1非标记 CAS：60-35-5中文名称：乙酰胺-d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (527 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Acetamide. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3:1211-21. [Content Brief][3]. Moore MM, et, al. The food contaminant acetamide is not an in vivo clastogen, aneugen, or mutagen in rodent hematopoietic tissue. Regul Toxicol Pharmacol. 2019 Nov108:104451. [Content Brief]
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「同位素标记抑制剂」CAS:14397-59-2|Isophorone-d8
作者：德尔塔生物 日期：2025-06-11
生物活性：Isophorone-d8 is the deuterium labeled Isophorone[1]. Isophorone, an α,β-unsaturated cyclic ketone, is used as a precursor to polymers[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：146.26Formula：C9H6D8OCAS 号：14397-59-2中文名称：异佛尔酮-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Dezvarei S, et al. Stereoselective hydroxylation of isophorone by variants of the cytochromes P450 CYP102A1 and CYP101A1. Enzyme Microb Technol. 2018 Apr;111:29-37. [Content Brief]
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「同位素标记抑制剂」CAS:15588-23-5|Hydroxylamine-d3 hydrochloride
作者：德尔塔生物 日期：2025-06-11
生物活性：Hydroxylamine-d3 (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Hydroxylamine-d3 hydrochloride 相关抗体:Monoamine Oxidase A Antibody (YA2036)Monoamine Oxidase B Antibody (YA2039)分子量：72.51Formula：ClHD3NOCAS 号：15588-23-5中文名称：盐酸羟胺-d3；羟胺盐酸盐-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (524 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Roh JH, et al. Purification, characterization, and crystallization of monoamine oxidase from Escherichia coli K-12. Biosci Biotechnol Biochem. 1994 Sep;58(9):1652-6. [Content Brief]
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