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「同位素标记抑制剂」CAS:1092804-87-9|Ranolazine-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ranolazine-d5 相关抗体:Annexin VI AntibodyxCT Antibody (YA006)Calbindin AntibodyCalreticulin AntibodyxCT Antibody (YA652)Cardiac Troponin I/TNNC1 AntibodyAlpha-ENaC AntibodySCGN Antibody (YA1167)RAMP1 Antibody (YA1818)Annexin V Antibody (YA1829)Striatin 4 Antibody (YA2088)Fibulin 5 Antibody (YA2448)RASGRP1 Antibody (YA2546)Fibulin 1 Antibody (YA2831)EFEMP1 Antibody (YA2883)CRCP Antibody (YA3350)CRMP2 Antibody (YA3370)Annexin VII Antibody (YA1138)Parvalbumin Antibody (YA1249)SLC12A1 Antibody (YA1403)Annexin IV Antibody (YA1921)SERCA2 ATPase Antibody (YA1931)CRMP1 Antibody (YA1941)Stromal Interaction Molecule 1 Antibody (YA2092)SERCA1 ATPase Antibody (YA2157)TrpV5 Antibody (YA2284)NCX1 Antibody (YA2331)Scramblase 1 Antibody (YA2419)CRMP5 Antibody (YA2497)CRMP3 Antibody (Y
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「同位素标记抑制剂」CAS:1189987-23-2|Leflunomide-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Leflunomide-d4 (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Leflunomide-d4 相关抗体:DPD Antibody (YA2000)分子量：274.23Formula：C12H5D4F3N2O2CAS 号：1189987-23-2非标记 CAS：75706-12-6中文名称：来氟米特 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (529 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Davis JP, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35(4):1270-3. [Content Brief][3]. Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398-403. [Content Brief][4]. Fox RI, et al. Mechanism of action for leflun
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「同位素标记抑制剂」CAS:162935-29-7|Propyphenazone-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Propyphenazone-d3 is the deuterium labeled Propyphenazone. Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as proagents and selective cyclooxygenase-2 inhibitors.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Propyphenazone-d3 相关抗体:COX2 AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCOX IV Antibody (YA867)Cyclooxygenase 1 Antibody (YA2537)Cyclooxygenase 2 Antibody (YA2541)分子量：233.32Formula：C14H15D3N2OCAS 号：162935-29-7非标记 CAS：479-92-5性状：固体颜色：White to off-white中文名称：异丙安替比林 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Burdan F, et al. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Cells Tissues Organs. 2002;171(2-3):145-51. [Content Brief]
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「同位素标记抑制剂」CAS:1616968-73-0|Ritonavir-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Ritonavir-d6 is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ritonavir-d6 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCD4 AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase Antibody分子量：726.98Formula：C37H42D6N6O5S2CAS 号：1616968-73-0非标记 CAS：155213-67-5性状：固体颜色：White to off-white中文名称：利托那韦 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1189922-23-3|Triamterene-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Triamterene-d5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.分子量：258.29Formula：C12H6D5N7CAS 号：1189922-23-3非标记 CAS：396-01-0性状：固体颜色：Light yellow to yellow中文名称：氨苯蝶啶 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1219802-26-2|Monoisobutyl phthalic acid-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Monoisobutyl phthalic acid-d4 is the deuterium labeled Monoisobutyl phthalic acid[1]. Monoisobutyl phthalic acid is a phthalate metabolite that is in human semen and in meconium[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Monoisobutyl phthalic acid-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：226.26Formula：C12H10D4O4CAS 号：1219802-26-2非标记 CAS：30833-53-5性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1553977-17-5|Ibrutinib-d5
作者：德尔塔生物 日期：2025-06-13
生物活性：Ibrutinib-d5 is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor[1].分子量：445.53Formula：C25H19D5N6O2CAS 号：1553977-17-5非标记 CAS：936563-96-1性状：固体颜色：White to off-white中文名称：依鲁替尼 d5运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：2 years-20°C：1 year
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「同位素标记抑制剂」CAS:25582-63-2|DPPC-d62
作者：德尔塔生物 日期：2025-06-13
生物活性：DPPC-d62 is the deuterium labeled DPPC. DPPC (129Y83) is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers[1]. DPPC-liposome serves effectively as a delivery vehicle for inducing immune responses against GSL antigen in mice[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.DPPC-d62 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：796.42Formula：C40H18D62NO8PCAS 号：25582-63-2非标记 CAS：63-89-8性状：固体颜色：White to off-white中文名称：二棕榈酰磷脂酰胆碱 d62运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 month
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「同位素标记抑制剂」CAS:1997338-61-0|Canagliflozin-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Canagliflozin-d4 is a deuterium labeled Canagliflozin. Canagliflozin is a selective SGLT2 inhibitor[1].IC50 & Target：SGLT2分子量：448.54Formula：C24H21D4FO5SCAS 号：1997338-61-0非标记 CAS：842133-18-0性状：固体颜色：Light yellow to light brown中文名称：卡格列净 d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 99.04%参考文献[1]. Liang Y, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012;7(2):e30555. [Content Brief]
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「同位素标记抑制剂」CAS:1304701-57-2|Edoxaban-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Edoxaban-d6 is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Edoxaban-d6 相关抗体:PAR2 Antibody (YA2455)Protein C Antibody (YA2461)Thrombomodulin Antibody (YA891)Thrombomodulin Antibody (YA892)F2 AntibodyPAR6 Antibody (YA1536)Prothrombin Antibody (YA1753)PAR4 Antibody (YA2603)Protein S Antibody (YA2919)Antithrombin III Antibody (YA3352)分子量：554.09Formula：C24H24D6ClN7O4SCAS 号：1304701-57-2非标记 CAS：480449-70-5性状：固体颜色：White to off-white中文名称：依度沙班-d6；伊多塞班-d6；艾多沙班-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： ≥99.0%
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「同位素标记抑制剂」CAS:1246304-34-6|D-erythro-Sphingosine-d7
作者：德尔塔生物 日期：2025-06-13
生物活性：D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.D-erythro-Sphingosine-d7 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyPFKFB3 AntibodyPhospho-PKC alpha (T638) AntibodyPhospho-PKC zeta (T560) AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)PKC alpha AntibodyPKC beta 1 AntibodyPKC beta 2 AntibodyPKC delta AntibodyPKC epsilon AntibodyPKC gamma AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 Antibody分子量：306.54Formula：C18H30D7NO2CAS 号：1246304-34-6非标记 CAS：123-78-4性状：固体颜色：White to off-white中文名称：D-赤式鞘氨醇 d7运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3
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「同位素标记抑制剂」CAS:1126623-89-9|Axitinib-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Axitinib-d3 (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1].分子量：389.49Formula：C22H15D3N4OSCAS 号：1126623-89-9非标记 CAS：319460-85-0性状：固体颜色：Off-white to light yellow中文名称：阿昔替尼 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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「同位素标记抑制剂」CAS:474668-57-0|Bupivacaine-d9
作者：德尔塔生物 日期：2025-06-13
生物活性：Bupivacaine-d99 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].IC50 & Target：NMDA Receptor分子量：297.48Formula：C18H19D9N2OCAS 号：474668-57-0非标记 CAS：38396-39-3性状：固体颜色：White to off-white中文名称：布比卡因-d9运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1276197-32-0|Pentamidine-d4 dihydrochloride
作者：德尔塔生物 日期：2025-06-13
生物活性：Pentamidine-d4 (dihydrochloride) is the deuterium labeled Pentamidine dihydrochloride. Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].IC50 & Target：Trypanosoma体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pentamidine-d4 dihydrochloride 相关抗体:PFKFB3 AntibodySDHA AntibodyDUSP1 AntibodyDUSP3 AntibodyMRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Intestinal Alkaline Phosphatase Antibody (YA1559)PFKL Antibody (YA1597)SHP2 Antibody (YA1643)PP1C alpha/beta Antibody (YA1700)PTP1B Antibody (YA1776)PLEKHA1 Antibody (YA2145)PGAM1 Antibody (YA2156)DUSP6 Antibody (YA2280)PRAS40 Antibody (YA3179)PPP4C Antibody (YA687)Sulfadimidine
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「同位素标记抑制剂」CAS:358730-93-5|Etidronic acid-d3 disodium
作者：德尔塔生物 日期：2025-06-13
生物活性：Etidronic acid-d3 (disodium) is the deuterium labeled Etidronic acid disodium[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Etidronic acid-d3 disodium 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)Fatty Acid Synthase AntibodyFIP200 Antibody分子量：253.01Formula：C2H3D3Na2O7P2CAS 号：358730-93-5非标记 CAS：7414-83-7性状：固体颜色：White to off-white中文名称：依替膦酸二钠-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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