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「同位素标记抑制剂」CAS:1279037-70-5|Scopolamine-d3 hydrobromide
作者：德尔塔生物 日期：2025-06-13
生物活性：Scopolamine-d3 (hydrobromide) is the deuterium labeled Scopolamine hydrobromide[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：387.28Formula：C17H19D3BrNO4CAS 号：1279037-70-5非标记 CAS：6533-68-2性状：固体颜色：White to off-white中文名称：东莨菪碱氢溴酸盐 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)纯度 & 产品资料纯度： 98.01%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:93131-16-9|Cyclohexanecarboxylic acid-d11
作者：德尔塔生物 日期：2025-06-13
生物活性：Cyclohexanecarboxylic acid-d11 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cyclohexanecarboxylic acid-d11 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：139.24Formula：C7HD11O2CAS 号：93131-16-9非标记 CAS：98-89-5性状：固体颜色：White to off-white中文名称：环己烷羧酸-d11运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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「同位素标记抑制剂」CAS:1331939-77-5|L-Ascorbic acid-13C6-1
作者：德尔塔生物 日期：2025-06-13
生物活性：L-Ascorbic acid-13C6-1 (L-Ascorbate-1; Vitamin C-13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166)[1]. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[2][3][4]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[5].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.L-Ascorbic acid-13C6-1 相关抗体:Annexin VI AntibodyBNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMETTL3 Antibodyc-Myc AntibodyCyclin E1 AntibodyTSG101 AntibodyAIF Antibody (YA636)ALIX AntibodyAlkaline Phosphatase AntibodyCalbindin AntibodyCalnexin Antibody (YA573)Calreticulin AntibodyCatalase Antibody (YA552)Catalase Antibody (YA811)分子量：182.08Formula：13C6H8O6CAS 号：1331939-77-5非标记 CAS：50-81-7性状：固体颜色：White to off-white中文名称：L-抗坏血酸-13C6-1； 维生素C-13C6-1运输条件：Room t
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「同位素标记抑制剂」CAS:1784060-40-7|6-Hydroxy Chlorzoxazone-15N,d2
作者：德尔塔生物 日期：2025-06-13
生物活性：6-Hydroxy Chlorzoxazone-15N,d2 is the 15N and deuterium labeled 6-Hydroxy Chlorzoxazone (HY-W016221)[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.6-Hydroxy Chlorzoxazone-15N,d2 相关抗体:FMO3 Antibody (YA1992)分子量：188.57Formula：C7H2D2Cl15NO3CAS 号：1784060-40-7性状：固体颜色：White to off-white中文名称：6-羟基氯唑沙宗-15N,d2运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:108395-15-9|2-Ketoglutaric acid-13C
作者：德尔塔生物 日期：2025-06-13
生物活性：2-Ketoglutaric acid-13C (Alpha-Ketoglutaric acid-13C) is a 13C labeled 2-Ketoglutaric acid (HY-W013636)[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2][3].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.2-Ketoglutaric acid-13C 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyMiTF AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)ZAP70 Antibody (YP4051)Asparagine Synthetase AntibodyCalnexin AntibodyCD3 epsilon AntibodyCD3D AntibodyKi67 Antibody (YA001)分子量：147.09Formula：C413CH6O5CAS 号：108395-15-9非标记 CAS：328-50-7性状：固体颜色：White to light yellow中文名称：α-酮戊二酸-13C运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 mont
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「同位素标记抑制剂」CAS:1413431-05-6|Ivacaftor-d18
作者：德尔塔生物 日期：2025-06-13
生物活性：Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ivacaftor-d18 相关抗体:Calumenin Antibody (YA813)分子量：410.60Formula：C24H10D18N2O3CAS 号：1413431-05-6非标记 CAS：873054-44-5性状：固体颜色：White to off-white中文名称：依伐卡托-d18运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料纯度： 92.92%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief][2]. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570. [Content Brief]
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「同位素标记抑制剂」CAS:1413431-22-7|Ivacaftor-d19
作者：德尔塔生物 日期：2025-06-13
生物活性：Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].体外研究(In Vitro)："氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。氘代化合物的潜在优势：（1）延长体内半衰期。氘代化合物或能够延长化合物的药代动力学特征，即延长体内半衰期。由此可提高化合物安全性、有效性和耐受性，并增加给药的便捷性。（2）提高口服生物利用度。氘代化合物或能够减少肠壁和肝脏中不需要的代谢 (首过代谢) 程度，使得更大比例的未代谢药物到达作用的目标位置。生物利用度高决定其在低剂量下具有活性以及更好的耐受性。（3）改善代谢特征。氘代化合物或能够减少有毒或反应性代谢物的形成，改善药物代谢状况。（4）改进药品安全性。氘代化合物或能够减少或消除药物化合物的不良副作用，具有安全性。（5）保留治疗特性。氘代化合物有望保留和此前研究中氢类似物相似的生化效力和选择性。"德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Ivacaftor-d19 相关抗体:Calumenin Antibody (YA813)分子量：411.61Formula：C24H9D19N2O3CAS 号：1413431-22-7非标记 CAS：873054-44-5中文名称：依伐卡托 d19运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (536 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann
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「同位素标记抑制剂」CAS:1802168-53-1|Cabozantinib-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Cabozantinib-d4 is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Cabozantinib-d4 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C AntibodyMet (C-Met) Antibodyc-Myc AntibodyCyclin E1 AntibodyPhospho-c-Met (Tyr1349) AntibodyAIF Antibody (YA636)ALIX Antibodyc-Kit Antibody (YA502)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 Antibody分子量：505.53Formula：C28H20D4FN3O5CAS 号：1802168-53-1非标记 CAS：849217-68-1中文名称：卡博替尼-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (531 KB)产品使用指南
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「同位素标记抑制剂」CAS:1803193-57-8|Pimozide-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Pimozide-d4 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].IC50 & Target[1][2][3]Dopamine D2 receptor1.4 nM (Ki)opamine D3 receptor2.5 nM (Ki)opamine D1 receptor588 nM (Ki)α1-adrenoceptor39 nM (Ki)STAT3STAT5Clinical TrialNCT NumberSponsorConditionStart DatePhaseNCT02374567Hannover Medical SchoolDementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety DisordersJanuary 2015Phase 3NCT02463825University of Calgary|Hotchkiss Brain Institute, University of CalgaryAmyotrophic Lateral Sclerosis (ALS)April 2015Phase 2NCT00374244Yale University|Stanley Medical Research InstituteSchizophreniaJanuary 2004Phase 2 NCT05507372Applied Biology, Inc.|Jupiter Wellness, Inc.Tinnitus, SubjectiveOctober 1, 2022Not ApplicableNCT00158223Icahn School of Medicine at Mount Sinai|National Institute of Mental Health (NIMH)Schizophrenia|Psychotic DisordersOctober 2004Phase 4NCT02600741Janssen Scientific Affairs, LLCSchizophreniaJuly 24, 2015NCT03272503University of Calgary|ALS Canada|Brain CanadaALS|Amyotrophic Lateral SclerosisOctober 27, 2017Phase 2NCT05716854Food and Drug Administration (FDA)|Spaulding Clinical Research LLCDrug-induced QT Prolongation|Pharmacokinetics|PharmacodynamicsMarch 21, 2023Phase 1NCT00004652National Center for Research Resources (NCRR)|University of Rochester|Office of Rare Diseases (ORD)Tourette SyndromeFebruary 1993Phase 2NCT0230
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「同位素标记抑制剂」CAS:58069-93-5|Dimethyl trisulfide-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Dimethyl trisulfide-d6 is deuterium labeled Dimethyl trisulfide (HY-128454). Dimethyl trisulfide is a cyanide antidote[1][2].分子量：132.30Formula：C2D6S3CAS 号：58069-93-5非标记 CAS：3658-80-8中文名称：二甲基三硫-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (518 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Rockwood GA, et al. Dimethyl trisulfide: A novel cyanide countermeasure. Toxicol Ind Health. 2016 Dec;32(12):2009-2016. [Content Brief]
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「同位素标记抑制剂」CAS:1346603-88-0|Alimemazine-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Alimemazine-d6 is deuterium labeled Alimemazine, which is an antihistamine.分子量：304.48Formula：C18H16D6N2SCAS 号：1346603-88-0非标记 CAS：4330-99-8性状：固体颜色：White to off-white中文名称：阿利马嗪-d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)纯度 & 产品资料纯度： 99.55%选择批次：HY-12752S-26****HY-12752S-19***Data Sheet (495 KB)SDS (252 KB)COA (269 KB)HNMR (115 KB)RP-HPLC (79 KB)LCMS (95 KB)产品使用指南 (1538 KB)
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「同位素标记抑制剂」CAS:133146-00-6|Yohimbine-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Yohimbine-d3 is the deuterium labeled Yohimbine (HY-12715)[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：357.46Formula：C21H23D3N2O3CAS 号：133146-00-6非标记 CAS：146-48-5性状：固体颜色：White to off-white中文名称：育亨宾 13C,d3-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1398044-45-5|Piribedil-d8
作者：德尔塔生物 日期：2025-06-13
生物活性：Piribedil-d8 is the deuterium labeled Piribedil, which is an antiparkinsonian agent.分子量：306.39Formula：C16H10D8N4O2CAS 号：1398044-45-5非标记 CAS：3605-01-4性状：固体颜色：White to off-white中文名称：吡贝地尔 d8；双哌嘧啶 d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2377109-74-3|Gilteritinib-d8
作者：德尔塔生物 日期：2025-06-13
生物活性：Gilteritinib-d8 is deuterium labeled Gilteritinib. Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Gilteritinib-d8 相关抗体:AXL AntibodyMERTK Antibody (YA2966)分子量：560.76Formula：C29H36D8N8O3CAS 号：2377109-74-3非标记 CAS：1254053-43-4性状：固体颜色：White to yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2408131-70-2|Bempedoic acid-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Bempedoic acid-d4 is the deuterium labeled Bempedoic acid. Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Bempedoic acid-d4 相关抗体:AMPK alpha AntibodyPhospho-AMPK alpha 2 (Thr172) AntibodyAMPK alpha 2 Antibody (YA833)Phospho-AMPK alpha 2(Ser345) AntibodyAMPK alpha 1 AntibodyAMPK alpha 1 Antibody (YA624)ATP citrate lyase AntibodyPhospho-AMPK alpha 1 (Ser496) Antibody (YA226)Phospho-Hormone sensitive lipase (Ser853) AntibodyATF4 Antibody (YA605)AMPK alpha 2 Antibody (YA623)AMPK beta 1 AntibodyAMPK gamma 1 AntibodyATF4 AntibodyATP Citrate Lyase Antibody (YA829)Phospho-AMPK alpha 1 (Ser496) AntibodyMARK2 Antibody (YA2104)MARK3 Antibody (YA2150)Phospho-Hormone Sensitive Lipase (Ser855) Antibody (YA2599)分子量：348.51Formula：C19H32D4O5CAS 号：2408131-70-2非标记 CAS：738606-46-7性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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