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「同位素标记抑制剂」CAS:1134163-31-7|Pioglitazone-d4 (alkyl)
作者：德尔塔生物 日期：2025-06-13
生物活性：Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pioglitazone-d4 (alkyl) 相关抗体:Ferritin Heavy Chain AntibodyPPAR alpha AntibodyPPAR gamma AntibodyPPAR gamma Antibody (YA122)AMID/FSP1 AntibodyPeroxiredoxin 1 Antibody (YA692)PRDX3 Antibody (YA909)Ferritin Light Chain Antibody (YA971)Ferritin Light Chain Antibody (YA972)PGC1 beta Antibody (YA1411)分子量：360.46Formula：C19H16D4N2O3SCAS 号：1134163-31-7非标记 CAS：111025-46-8性状：固体颜色：White to off-white中文名称：吡格列酮 d4 (alkyl)运输条件：Room temperature in continental US; may vary elsewhere.储存方式：-20°C, protect from light, stored under nitrogen*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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「同位素标记抑制剂」CAS:136765-31-6|Dothiepin-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Dothiepin-d3 is the deuterium labeled Dothiepin[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.分子量：298.46Formula：C19H18D3NSCAS 号：136765-31-6非标记 CAS：113-53-1性状：固体颜色：Off-white to light yellow中文名称：度硫平-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料Data Sheet (522 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
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「同位素标记抑制剂」CAS:2749331-28-8|Gepirone-d8
作者：德尔塔生物 日期：2025-06-13
生物活性：Gepirone-d8 is deuterium labeled Gepirone.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Gepirone-d8 相关抗体:MTNR1A Antibody分子量：367.52Formula：C19H21D8N5O2CAS 号：2749331-28-8非标记 CAS：83928-76-1性状：固体颜色：White to off-white中文名称：吉哌隆-d8运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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「同位素标记抑制剂」CAS:1793055-05-6|3-Phenoxybenzoic acid-13C6
作者：德尔塔生物 日期：2025-06-13
生物活性：3-Phenoxybenzoic acid-13C6 is the 13C6 labeled 3-Phenoxybenzoic acid. 3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.3-Phenoxybenzoic acid-13C6 相关抗体:ERK1/2 AntibodyE-Cadherin Antibody (YA470)Fatty Acid Synthase Antibody (YA766)DYKDDDDK Tag (FLAG) AntibodyGAPDH AntibodyGFP Antibodyp53 Antibody (YA250)RUNX2 AntibodyFerritin Heavy Chain AntibodyCOX2 AntibodyCtip2 AntibodyCyclin D1 Antibody (YA485)Cytochrome C Antibodyc-Myc AntibodyCyclin E1 AntibodyAIF Antibody (YA636)ALIX AntibodyCatalase Antibody (YA552)Catalase Antibody (YA811)CNPase AntibodyCortactin AntibodyCOX IV AntibodyCOX2/Cyclooxygenase 2 AntibodyCyclin A2 AntibodyCyclin B1 Antibody (YA486)DR5 AntibodyDrosha AntibodyE-Cadherin Antibody (YA778)EEA1 AntibodyEpCAM Antibody (YA772)分子量：220.17Formula：C713C6H10O3CAS 号：1793055-05-6非标记 CAS：3739-38-6性状：固体颜色：White to off-white中文名称：3-苯氧基苯甲酸-13C6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months
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「同位素标记抑制剂」CAS:1217462-49-1|Aflatoxin G2-13C17
作者：德尔塔生物 日期：2025-06-13
生物活性：Aflatoxin G2-13C17 is the 13C labeled Aflatoxin G2 (HY-N6698)[1]. Aflatoxin G2 is a major naturally produced aflatoxin that can be produced by the fungi Aspergillus flavus and Aspergillus parasiticus[1].体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Aflatoxin G2-13C17 相关抗体:MRP2 AntibodyElongation factor 2 Antibody (YA962)Elongation factor 2 Antibody (YA964)PU.1/SPI1 Antibody (YA1116)Sulfadimidine Antibody (YA906)Elongation factor 2 Antibody (YA963)Anthrax Protective gen Antibody (YA1060)Elongation factor 1 gamma Antibody (YA2004)Pulmonary Surfactant Associated Protein D Antibody (YA2107)Cathelicidin Antibody (YA2380)Elongation Factor Ts Antibody (YA2524)Elongation Factor 1A2 Antibody (YA2879)BPI Antibody (YA3068)MetRS Antibody (YA3196)分子量：347.16Formula：13C17H14O7CAS 号：1217462-49-1非标记 CAS：7241-98-7性状：液体颜色：Colorless to light yellow中文名称：黄曲霉毒素 G2-13C17运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.纯度 & 产品资料纯度： ≥98.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-220. [Content Brief][2]. Kumar P, et al. Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management. Front Microb
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「同位素标记抑制剂」CAS:2001098-07-1|N-Acetyl-5-hydroxytryptamine-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.N-Acetyl-5-hydroxytryptamine-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTrkA AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)TrkB AntibodyLaminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyBDNF AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量：221.27Formula：C12H11D3N2O2CAS 号：2001098-07-1非标记 CAS：1210-83-9性状：固体颜色：White to off-white中文名称：N-乙酰基血清素-d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:124629-74-9|Leukotriene B4-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Leukotriene B4-d4 is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Leukotriene B4-d4 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：340.49Formula：C20H28D4O4CAS 号：124629-74-9非标记 CAS：71160-24-2性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Solution, -20°C,
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「同位素标记抑制剂」CAS:1245477-09-1|Oleoylethanolamide-d2
作者：德尔塔生物 日期：2025-06-13
生物活性：Oleoylethanolamide-d2 is the deuterium labeled Oleoylethanolamide. Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Oleoylethanolamide-d2 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyPPAR alpha AntibodyMETTL3 AntibodyPPAR gamma AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)PPAR gamma Antibody (YA122)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin Antibody分子量：327.54Formula：C20H37D2NO2CAS 号：1245477-09-1非标记 CAS：111-58-0性状：液体颜色：Colorless to light yellow运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Solution, -20°C, 2 years纯度 & 产品资料纯度： ≥98.0%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on
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「同位素标记抑制剂」CAS:1173148-04-3|Pyridoxal-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Pyridoxal-d3 is the deuterium labeled Pyridoxal[1].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pyridoxal-d3 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyMETTL3 AntibodyTSG101 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)Lamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)OPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)Laminin beta 1 AntibodyHeme Oxygenase 1 AntibodyKi67 Antibody (YA717)Ki67 Antibody (YA322)Asparagine Synthetase AntibodyCalnexin AntibodyKi67 Antibody (YA001)Osteopontin AntibodySynaptophysin Antibody (YA664)TREM2 AntibodyGAPDH Antibody (YA848)分子量：170.18Formula：C8H6D3NO3CAS 号：1173148-04-3非标记 CAS：66-72-8性状：固体颜色：White to off-white运输条件：Room temperature in continental US; may vary elsewhere.储存方式：4°C, sealed storage, away from moisture and light*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)纯度 & 产品资料纯度： 99.15%参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 20
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「同位素标记抑制剂」CAS:362049-65-8|Valproic acid-d15
作者：德尔塔生物 日期：2025-06-13
生物活性：Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Valproic acid-d15 相关抗体:BNSP AntibodyFACL4 AntibodyBrdU Antibody (YA578)GAPDH AntibodyGlucose 6 Phosphate Dehydrogenase AntibodyHDAC1 AntibodyHDAC6 AntibodyMETTL3 AntibodyHDAC4 Antibody (YA741)TSG101 AntibodySATB2 AntibodyAlkaline Phosphatase AntibodyCalnexin Antibody (YA573)CD4 AntibodyHDAC10 AntibodyHDAC2 AntibodyHDAC3 AntibodyHDAC4 AntibodyJagged1 AntibodyLamin A/C AntibodyLamin B1 AntibodyLAMP1 AntibodyLAMP2 Antibody (YA713)LAMP2a AntibodyNQO1 Antibody (YA697)NQO1 Antibody (YA261)NUMB AntibodyOPA1 AntibodyRBM3 AntibodySynaptophysin Antibody (YA043)分子量：159.30Formula：C8HD15O2CAS 号：362049-65-8非标记 CAS：99-66-1性状：液体（密度：0.91 g/cm3）颜色：Colorless to light yel
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「同位素标记抑制剂」CAS:1255386-16-3|Regorafenib-d3
作者：德尔塔生物 日期：2025-06-13
生物活性：Regorafenib-d3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor[1].分子量：485.83Formula：C21H12D3ClF4N4O3CAS 号：1255386-16-3非标记 CAS：755037-03-7性状：固体颜色：White to off-white中文名称：瑞戈非尼 d3运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:2098655-51-5|Betrixaban-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Betrixaban-d6 is a deuterium labeled Betrixaban. Betrixaban is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor[1].分子量：457.94Formula：C23H16D6ClN5O3CAS 号：2098655-51-5非标记 CAS：330942-05-7性状：固体颜色：White to off-white中文名称：贝曲西班 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1126721-82-1|Sunitinib-d10
作者：德尔塔生物 日期：2025-06-13
生物活性：Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].IC50 & Target[1]：VEGFR280 nM (IC50)PDGFRβ2 nM (IC50)分子量：408.54Formula：C22H17D10FN4O2CAS 号：1126721-82-1非标记 CAS：557795-19-4性状：固体颜色：White to yellow中文名称：舒尼替尼 d10运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month
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「同位素标记抑制剂」CAS:1219592-01-4|Pazopanib-d6
作者：德尔塔生物 日期：2025-06-13
生物活性：Pazopanib-d6 is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Pazopanib-d6 相关抗体:FGFR2/CD332 Antibodyc-Kit Antibody (YA502)Phospho-PDGFR beta (Y740) AntibodyVEGF Receptor 2 Antibody (YA014)FGFR1 AntibodyFGFR1 Oncogene Partner AntibodyFGFR2 AntibodyFGFR3 AntibodyPDGFR alpha AntibodyFGF2 AntibodyVEGF Receptor 1 AntibodyVEGFA AntibodyVEGF Receptor2 Antibody FGF1 Antibody (YA1430)PDGF B Antibody (YA1556)FGFR4 Antibody (YA1588)PLGF Antibody (YA1812)PDGFR beta Antibody (YA1925)VEGFD Antibody (YA2385)FGF19 Antibody (YA2672)TACC3 Antibody (YA2921)Phospho-PDGFR beta (Tyr740) Antibody (YA3062)FGF21 Antibody (YA3276)c-Kit AntibodySCF AntibodyPGF Antibody (YA1434)Neuropilin 1 Antibody (YA1831)VEGFB Antibody (YA2627)分子量：443.55Formula：C21H17D6N7O2SCAS 号：1219592-01-4非标记 CAS：444731-52-6性状：固体颜色：White to off-white中文名称：帕唑帕尼 d6运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 mon
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「同位素标记抑制剂」CAS:1618637-32-3|Dabigatran-d4
作者：德尔塔生物 日期：2025-06-13
生物活性：Dabigatran-d4 is deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.Dabigatran-d4 相关抗体:PAR2 Antibody (YA2455)Protein C Antibody (YA2461)Thrombomodulin Antibody (YA891)Thrombomodulin Antibody (YA892)F2 AntibodyPAR6 Antibody (YA1536)Prothrombin Antibody (YA1753)PAR4 Antibody (YA2603)Protein S Antibody (YA2919)分子量：475.54Formula：C25H21D4N7O3CAS 号：1618637-32-3非标记 CAS：211914-51-1性状：固体颜色：White to off-white中文名称：达比加群-d4运输条件：Room temperature in continental US; may vary elsewhere.储存方式：Powder：-20°C：3 years，4°C：2 yearsIn solvent：-80°C：6 months，-20°C：1 month纯度 & 产品资料Data Sheet (528 KB)产品使用指南 (1538 KB)参考文献[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief][2]. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66. [Content Brief][3]. Wie
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